Maksymowych W P, Aaron S L, Russell A S
Department of Medicine, University of Alberta, Edmonton, Canada.
J Rheumatol. 2001 Dec;28(12):2754-7.
Osteitis pubis is a noninfectious painful inflammatory disorder of the symphysis pubis. Etiologic factors include urologic procedures, abdomino-perineal and gynecological surgery, and spondyloarthropathies, although many cases are idiopathic. Most respond to conservative measures consisting primarily of rest and analgesic/antiinflammatory agents. We describe 3 cases, 2 with idiopathic osteitis pubis and one that was associated with a spondyloarthropathy, that failed to respond to conservative measures but experienced clinical remission with 3 to 6 monthly courses of intravenous pamidronate. Remission was also evident in 2 patients on isotope bone scan. Followup has revealed no recurrence. Intravenous pamidronate may constitute a safe and effective treatment option for patients with refractory osteitis pubis.
耻骨炎是一种耻骨联合处的非感染性疼痛性炎症性疾病。病因包括泌尿外科手术、腹会阴和妇科手术以及脊柱关节病，尽管许多病例是特发性的。大多数患者对主要包括休息和止痛/抗炎药物的保守治疗有反应。我们描述了3例病例，2例为特发性耻骨炎，1例与脊柱关节病相关，这些病例对保守治疗无反应，但通过每月3至6个疗程的静脉注射帕米膦酸实现了临床缓解。2例患者的同位素骨扫描也显示缓解。随访未发现复发。静脉注射帕米膦酸可能是难治性耻骨炎患者的一种安全有效的治疗选择。
