Cryer B
Medical Service, Dallas Veterans Affairs Medical Center, Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.
Gastroenterol Clin North Am. 2001 Dec;30(4):877-94, v-vi. doi: 10.1016/s0889-8553(05)70218-1.
When considering the diseases of the stomach and duodenum, peptic ulcer disease has been the one of greatest clinical impact. Although there are several components that contribute mechanistically to ulcer disease, it is recognized that gastroduodenal mucosal prostaglandins play a central pathogenic role, especially in ulcers related to the use of NSAIDs. As a result of understanding the mechanisms of NSAID-induced ulceration, the crucial function that gastroduodenal mucosal prostaglandins have in mucosal defense and repair is appreciated. It now is held widely that mucosal prostaglandin deficiency increases susceptibility to ulcer formation and that exogenous administration of supplemental prostaglandins reduces ulcer risk. This article reviews the role that mucosal prostaglandins play in defense of the gastric and duodenal mucosa against injury and ulceration.
在考虑胃和十二指肠疾病时，消化性溃疡病一直是具有最大临床影响的疾病之一。尽管有几个因素在机制上促成溃疡病，但人们认识到胃十二指肠黏膜前列腺素起着核心致病作用，尤其是在与使用非甾体抗炎药相关的溃疡中。由于了解了非甾体抗炎药诱发溃疡的机制，胃十二指肠黏膜前列腺素在黏膜防御和修复中的关键作用得到了认识。现在人们普遍认为，黏膜前列腺素缺乏会增加溃疡形成的易感性，而外源性补充前列腺素可降低溃疡风险。本文综述了黏膜前列腺素在保护胃和十二指肠黏膜免受损伤和溃疡方面所起的作用。
