Tateshima S, Murayama Y, Villablanca J P, Morino T, Takahashi H, Yamauchi T, Tanishita K, Vinuela F
Department of Radiological Sciences, University of California at Los Angeles School of Medicine and Medical Center, Los Angeles, California 90024, USA.
J Neurosurg. 2001 Dec;95(6):1020-7. doi: 10.3171/jns.2001.95.6.1020.
To obtain precise flow profiles in patients' aneurysms, the authors developed a new in vitro study method featuring an aneurysm model manufactured using three-dimensional computerized tomography (3D CT) angiography.
A clear acrylic basilar artery (BA) tip aneurysm model manufactured from a patient's 3D CT angiogram was used to analyze flow modifications during one cardiac cycle. Stereolithography was utilized to create the aneurysm model. Three-dimensional flow profiles within the aneurysm model were obtained from velocity measurements by using laser Doppler velocimetry. The aneurysm inflow/outflow zones changed dynamically in their location, size of their cross-sectional area, and also in their shapes over one cardiac cycle. The flow velocity at the inflow zone was 16.8 to 81.9% of the highest axial velocity in the BA with a pulsatility index (PI) of 1.1. The flow velocity at the outflow zone was 16.8 to 34.3% of the highest axial velocity of the BA, with a PI of 0.68. The shear stress along the walls of the aneurysm was calculated from the fluid velocity measured at a distance of 0.5 mm from the wall. The highest value of shear stress was observed at the bleb of the aneurysm.
This clear acrylic model of a BA tip aneurysm manufactured using a CT angiogram allowed qualitative and quantitative analysis of its flow during a cardiac cycle. Accumulated knowledge from this type of study may reveal pertinent information about aneurysmal flow dynamics that will help practitioners understand the relationship among anatomy, flow dynamics, and the natural history of aneurysms.
为了获取患者动脉瘤内精确的血流剖面，作者开发了一种新的体外研究方法，该方法以使用三维计算机断层扫描（3D CT）血管造影制造的动脉瘤模型为特色。
使用从患者的3D CT血管造影制造的透明丙烯酸基底动脉（BA）尖端动脉瘤模型来分析一个心动周期内的血流变化。利用立体光刻技术创建动脉瘤模型。通过使用激光多普勒测速仪进行速度测量，获得动脉瘤模型内的三维血流剖面。在一个心动周期内，动脉瘤的流入/流出区域在其位置、横截面积大小以及形状方面都动态变化。流入区域的流速为基底动脉最高轴向流速的16.8%至81.9%，搏动指数（PI）为1.1。流出区域的流速为基底动脉最高轴向流速的16.8%至34.3%，PI为0.68。沿着动脉瘤壁的剪切应力是根据在距离壁0.5毫米处测量的流体速度计算得出的。在动脉瘤的小泡处观察到剪切应力的最高值。
这个使用CT血管造影制造的透明丙烯酸基底动脉尖端动脉瘤模型允许对其心动周期内的血流进行定性和定量分析。这类研究积累的知识可能揭示有关动脉瘤血流动力学的相关信息，这将有助于从业者理解解剖结构、血流动力学和动脉瘤自然病史之间的关系。
