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新型普罗布考类似物及其与α-生育酚组合的抗氧化作用

[Antioxidant effect of novel probucol analogs and their combinations with alpha-tocopherol].

作者信息

Storozhok N M, Krysin A P, Gureeva N V

机构信息

Tyumen State Medical Academy, 625023, Tyumen, st Odesskaya, 52.

出版信息

Vopr Med Khim. 2001 Sep-Oct;47(5):517-25.

PMID:11766263
Abstract

The antioxidant and antiradical activities of sulfur containing phenols which are analogues of probucol in comparison with alpha-tocopherol and BHT were tested using initiated methyl oleate oxidation model. The antioxidant effect linearly increased with increasing concentration of phenols. The ability of investigated phenols to destroy and reduced accumulation of hydroperoxides is revealed. The combined inhibitory effects of composition most effective researched antioxidant--CO-3--with alpha-tocopherol for the first time are described.

摘要

使用油酸甲酯氧化引发模型,测试了与普罗布考类似的含硫酚类化合物相对于α-生育酚和丁基羟基甲苯(BHT)的抗氧化和抗自由基活性。抗氧化作用随酚类化合物浓度的增加呈线性增加。研究发现了所研究酚类破坏和减少氢过氧化物积累的能力。首次描述了最有效的研究抗氧化剂组合物——CO - 3与α-生育酚的联合抑制作用。

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