Storozhok N M, Tsymbal I N, Petrenko N I, Shul'ts E E, Khrapova N G, Tolstikov G A, Burlakova E B
Tyumen State Medical Academy, 625023, Thymen, Odesskaya st, 54.
Biomed Khim. 2003 Jan-Feb;49(1):96-104.
In modeling system of the initiated oxidation of methyl oleate the antioxidation activity of a series of dipeptide derivatives of betulonic and glycyrrhetic acids, natural quinones (ubiquinone, philloquinone and menadione) and the kinetic effects of their combined action with alpha-tocopherol were studied. The same extreme character of the dependence of inhibitory action on the concentration of all investigated substances was found. Combined addition of triterpenoids or quinones together with alpha-tocopherol attenuated their effect. The mechanism of intermolecular interactions of tocopherol with quinones and triterpenoids is offered. The biological importance of these effects is discussed.
在油酸甲酯起始氧化的建模系统中，研究了一系列桦木酸和甘草次酸的二肽衍生物、天然醌类（泛醌、叶绿醌和甲萘醌）的抗氧化活性及其与α-生育酚联合作用的动力学效应。发现所有研究物质的抑制作用对浓度的依赖性具有相同的极端特征。三萜类化合物或醌类与α-生育酚联合添加会减弱它们的作用。提出了生育酚与醌类和三萜类化合物的分子间相互作用机制。讨论了这些效应的生物学重要性。
