Mariani C L, Platt S R, Newell S M, Terrell S P, Chrisman C L, Clemmons R M
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Health Science Center, University of Florida, Gainesville 32610-0126, USA.
Vet Radiol Ultrasound. 2001 Nov-Dec;42(6):524-31. doi: 10.1111/j.1740-8261.2001.tb00981.x.
A 3-year-old neutered female mixed breed dog was examined because of severe, generalized seizure activity, tetraparesis, and encephalopathic signs. Cerebrospinal fluid (CSF) evaluation was unremarkable except for a mild increase in protein. Serum and CSF titers for infectious diseases were negative. Magnetic resonance (MR) imaging examination of the brain was performed and lesions were found within the cerebral gray matter of the temporal and parietal lobes. The lesions had increased signal intensity on T1, T2, and proton density-weighted images. There was mild inhomogeneous enhancement following intravenous contrast medium administration. Neurologic status improved and the seizures were well controlled, but the dog never regained normal mentation and euthanasia was performed 10 weeks after initial evaluation. At necropsy, severe cerebral cortical necrosis was found in the regions corresponding to the lesions seen on MR imaging examination. Large numbers of fat-containing macrophages (gitter cells) were found within these areas, and are thought to be responsible for the characteristic hyperintensity seen on the MR images.
一只3岁已绝育的雌性混种犬因严重的全身性癫痫发作、四肢轻瘫和脑病体征而接受检查。脑脊液（CSF）评估除蛋白轻度升高外无异常。传染病的血清和脑脊液滴度均为阴性。对脑部进行了磁共振（MR）成像检查，发现颞叶和顶叶的脑灰质内有病变。这些病变在T1、T2和质子密度加权图像上信号强度增加。静脉注射造影剂后有轻度不均匀强化。神经状态有所改善，癫痫得到良好控制，但该犬从未恢复正常精神状态，在初次评估10周后实施了安乐死。尸检时，在与MR成像检查所见病变相对应的区域发现了严重的脑皮质坏死。在这些区域发现了大量含脂肪的巨噬细胞（格子细胞），被认为是MR图像上特征性高信号的原因。
