Kuszmann J
Gyógyszerkutató Intézet, Kft. 1325-Budapest, Pf 82.
Acta Pharm Hung. 2001;71(1):57-66.
This paper deals with results of the search for anticancer agents achieved at IDR during the period of 1953-1983. This research activity concentrated on the following four topics: 1) biological alkylating agents, 2) nucleoside type antimetabolites, 3) anthracyclin antibiotics and 4) analogs of tamoxifen. Among those the first one was the most successful, resulting in five new cytostatics, which were marketed under the tradename Degranol [1,6-bis-(2-chloroethylamino)-1,6-dideoxy-D-mannitol], Mannogranol [1,6-dibromo-1,6-dideoxy-D-mannitol], Myelobromol [1,6-dibromo-1,6-dideoxy-galactitol], Zytostop [1,2,5,6-tetra-O-methanesulfonyl-D-mannitol] and Lycurim [1,4-bis-(mesyloxiethylamino)-1,4-dideoxy-eryhtritol].
本文论述了1953年至1983年期间在药物研究与发展研究所（IDR）开展的抗癌药物研究成果。该研究活动集中在以下四个主题上：1）生物烷化剂，2）核苷类抗代谢物，3）蒽环类抗生素，4）他莫昔芬类似物。其中第一个主题最为成功，研发出了五种新的细胞抑制剂，它们以商品名Degranol[1,6-双-(2-氯乙氨基)-1,6-二脱氧-D-甘露糖醇]、Mannogranol[1,6-二溴-1,6-二脱氧-D-甘露糖醇]、Myelobromol[1,6-二溴-1,6-二脱氧-半乳糖醇]、Zytostop[1,2,5,6-四-O-甲磺酰基-D-甘露糖醇]和Lycurim[1,4-双-(甲磺酰氧基乙氨基)-1,4-二脱氧-赤藓醇]上市销售。
