Sun Z, Gong Y, Huang J
Department of Oral Medicine, Beijing Hospital for Stomatology, Capital University of Medical Sciences, Beijing 100050, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2001 Sep;36(5):364-6.
To explore the clinical significance of the LSCP (lesion size, site of lesion, clinical aspects, pathological aspects) classification and staging system through a comprehensive analysis of relationships between the risk factors of malignant transformation of 209 cases with oral leukoplakia and the LSCP classification and staging system.
Single factor Chi-square test was first performed to examine the associations between LSCP stages (I, II, III, IV) of oral leukoplakia and each of risk factors, including sex, site, size, numbers of lesion, alcohol and tobacco consumption, clinical classification and histopathological classification respectively, to select the most significant factors which influence the LSCP classification and staging. Then, the association of these selected factors with LSCP stages of oral leukoplakia (stage IV vs. I, II and III) was evaluated using multiple logistic regression analysis.
Sex, site of lesions, clinical aspect and histopathological features of lesions were chosen as risk factors incorporated into the multiple logistic regression models. The results demonstrated that the risk of oral leukoplakia of the female patients classified as LSCP stage IV was 2.49 times as high as that of the male patients. The risk of lesions occurring in tongue and/or that floor of mouth was higher than that in other sites. Among the different clinical subtypes of lesions, the verrucous leukoplakia was the highest and 10.00 times as high as that of the homogeneous one. Among the different histopathological types, when hyperplasia and mild dysplasia were set as the basic level, the risk of severe dysplasia classified as LSCP stage IV was the highest and 499.55 times as high as the basic level, while that of moderate dysplasia was 276.48 times as high as the basic level. Pathological features with moderate and severe dysplasia were the most important contributory factors to the LSCP staging.
The LSCP classification and staging system provides a comprehensive description of the features of oral leukoplakia, which is helpful in evaluating the overall risk of malignant transformation of oral lesion, and is valuable in clinical follow-up and developing the best treatment plan.
通过综合分析209例口腔白斑恶变危险因素与LSCP（病变大小、病变部位、临床特征、病理特征）分类及分期系统之间的关系，探讨LSCP分类及分期系统的临床意义。
首先进行单因素卡方检验，分别考察口腔白斑的LSCP分期（I、II、III、IV期）与各危险因素，包括性别、部位、大小、病变数量、烟酒消耗、临床分类及组织病理学分类之间的关联，以筛选出影响LSCP分类及分期的最显著因素。然后，采用多因素logistic回归分析评估这些选定因素与口腔白斑LSCP分期（IV期与I、II、III期）之间的关联。
将性别、病变部位、临床特征及病变的组织病理学特征作为危险因素纳入多因素logistic回归模型。结果显示，LSCP分期为IV期的女性口腔白斑患者恶变风险是男性患者的2.49倍。病变发生于舌和/或口底的风险高于其他部位。在不同临床亚型的病变中，疣状白斑的恶变风险最高，是均质型白斑的10.00倍。在不同组织病理学类型中，以增生和轻度不典型增生为基础水平，LSCP分期为IV期的重度不典型增生恶变风险最高，是基础水平的499.55倍，中度不典型增生是基础水平的276.48倍。中重度不典型增生的病理特征是LSCP分期的最重要影响因素。
LSCP分类及分期系统全面描述了口腔白斑的特征，有助于评估口腔病变恶变的总体风险，对临床随访及制定最佳治疗方案具有重要价值。
