雌激素乳膏防治绝经后女性复发性泌尿系统感染

[Prevention and treatment of recurrent urinary system infection with estrogen cream in postmenopausal women].

作者信息

Xu R, Wu Y, Hu Y

机构信息

Department of Obstetrics and Gynecology, Beijing Hospital, Ministry of Public Health, Beijing 100730, China.

出版信息

Zhonghua Fu Chan Ke Za Zhi. 2001 Sep;36(9):531-3.

PMID:11769665

Abstract

OBJECTIVE

To evaluate the effect and feasibility of using estrogen cream for the prevention and treatment of recurrent urinary tract infection (UTI) in postmenopausal women.

METHODS

Forty-five postmenopausal women with a history of recurrent UTI were divided into two groups (group premarin and group antibiotic). Participants were assigned to apply intravaginal premarin cream (group premarin, n = 30) or oral antibiotic (group antibiotic, n = 15) for 3 months respectively. Urine routine test, midstream urine and vaginal cultures, vaginal health score (VHS), vaginal cell maturation value (MV), endometrial thickness and blood estrogen level were obtained before and after the study.

RESULTS

The incidence of UTI in the group premarin was significantly reduced as compared with that in the group antibiotic (2/27 vs. 12/15, P < 0.001). In the group premarin Lactobacilli reappeared (from 0 to 59.3%) and MV (from 9.2 +/- 6.8 to 74.6 +/- 14.1) and VHS (from 5.2 +/- 0.4 to 13.4 +/- 2.5) were improved after 3 months. There was no significant change in the group antibiotic.

CONCLUSION

It seems that intravaginal use of estrogen cream would effectively prevent and reduce the UTI in postmenopausal women.

摘要

目的

评估使用雌激素乳膏预防和治疗绝经后女性复发性尿路感染（UTI）的效果及可行性。

方法

将45例有复发性UTI病史的绝经后女性分为两组（倍美力组和抗生素组）。参与者分别被分配使用阴道内倍美力乳膏（倍美力组，n = 30）或口服抗生素（抗生素组，n = 15），为期3个月。在研究前后获取尿常规、中段尿和阴道培养物、阴道健康评分（VHS）、阴道细胞成熟值（MV）、子宫内膜厚度和血液雌激素水平。