Oxford J S
J Gen Virol. 1975 Sep;28(3):409-14. doi: 10.1099/0022-1317-28-3-409.
A synthetic nucleoside analogue 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboamide (ribavirin or RTCA) inhibits the replication of tissue culture of influenza B virus and also a wide range of influenza A viruses of human, animal and avian origin. The synthesis of influenza virus-induced antigens and also structural and non-structural polypeptides is inhibited by RTCA as detected by immunofluorescence and by pulse labelling experiments with [35S]-methionine. The inhibitory effects of RTCA on influenza A virus replication in tissue culture is reversed by a molar excess of guanosine or zanthosine which suggests that the compound acts at an early stage of virus RNA synthesis prior to the utilisation of the latter nucleosides. A possible inhibitory effect of RTCA on cellular DNA replication is not excluded.
一种合成核苷类似物1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺（利巴韦林或RTCA）可抑制乙型流感病毒在组织培养中的复制，也能抑制多种人类、动物和禽类来源的甲型流感病毒。通过免疫荧光以及用[35S]-甲硫氨酸进行脉冲标记实验检测发现，RTCA可抑制流感病毒诱导抗原以及结构和非结构多肽的合成。在组织培养中，过量的鸟苷或黄嘌呤核苷可逆转RTCA对甲型流感病毒复制的抑制作用，这表明该化合物在病毒RNA合成的早期阶段起作用，且发生在利用后两种核苷之前。不排除RTCA对细胞DNA复制可能存在的抑制作用。
