Dawson W O, Lozoya-Saldana H
Intervirology. 1984;22(2):77-84. doi: 10.1159/000149537.
Ribavirin inhibited a specific step of tobacco mosaic virus (TMV) replication. Time-courses of sensitivity of TMV multiplication in asynchronous and synchronous infections demonstrated that ribavirin inhibited an early function that occurs prior to the period of viral RNA and protein synthesis. In the synchronous infection, ribavirin inhibited the synthesis of both single-stranded genomic RNA and double-stranded replicative form RNA when treatment began during the first 4 h, but there was no inhibition when treatment began at 12 h or later, even though most RNA synthesis occurred after 12 h. Viral protein synthesis also was inhibited when treatment began during the first 4 h and not when treatment began later. Unlike the mechanisms proposed against animal viruses, ribavirin appears to inhibit TMV replication by preventing an early function that is necessary to initiate viral RNA synthesis.
利巴韦林抑制烟草花叶病毒（TMV）复制的一个特定步骤。在异步感染和同步感染中TMV增殖敏感性的时间进程表明，利巴韦林抑制了病毒RNA和蛋白质合成期之前发生的早期功能。在同步感染中，当在最初4小时内开始处理时，利巴韦林抑制单链基因组RNA和双链复制形式RNA的合成，但当在12小时或更晚开始处理时则没有抑制作用，即使大多数RNA合成在12小时后发生。当在最初4小时内开始处理时病毒蛋白质合成也受到抑制，而在较晚开始处理时则不受抑制。与针对动物病毒提出的机制不同，利巴韦林似乎通过阻止启动病毒RNA合成所必需的早期功能来抑制TMV复制。
