Yang L, Zhu S, Wang X
Department of Cardiology, Kunming General Hospital, Chengdu Military Area, Kunming 650032, China.
Zhonghua Nei Ke Za Zhi. 2001 Oct;40(10):660-2.
To explore the pathophysiological role of cytokine network and their endogenous modulators in the development of congestive heart failure (CHF).
Plasma levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6(IL-6), soluble TNF receptor I (sTNF-RI) and transforming growth factor (TGF)-beta were measured by enzyme-linked immunoassay in 52 CHF patients with various degrees of heart failure and in 30 healthy controls.
Patients with CHF had increased plasma concentrations of TNF alpha, IL-6 and sTNF-RI, but decreased levels of TGF-beta. They also had elevated ratios of TNF-alpha/sTNF-RI and TNF-alpha/TGF-beta, particularly those in functional class IV. The levels of TNF-alpha were positively correlated with IL-6 and sTNF-RI but negatively correlated with TGF-beta(P < 0.01).
The imbalance in the cytokine network were most pronounced in patients with the most severe heart failure. CHF may be accompanied by a shift toward enhanced levels of inflammatory cytokines combined with inadequately raised or even decreased levels of anti-inflammatory cytokines. A poorly regulated cytokine network may be involved in the development and progression of CHF.
探讨细胞因子网络及其内源性调节因子在充血性心力衰竭（CHF）发生发展中的病理生理作用。
采用酶联免疫吸附测定法，检测52例不同程度心力衰竭的CHF患者及30例健康对照者血浆中肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、可溶性TNF受体I（sTNF-RI）和转化生长因子（TGF）-β的水平。
CHF患者血浆中TNF-α、IL-6和sTNF-RI浓度升高，但TGF-β水平降低。他们的TNF-α/sTNF-RI和TNF-α/TGF-β比值也升高，尤其是心功能IV级患者。TNF-α水平与IL-6和sTNF-RI呈正相关，但与TGF-β呈负相关（P<0.01）。
细胞因子网络失衡在最严重心力衰竭患者中最为明显。CHF可能伴随着炎症细胞因子水平升高，同时抗炎细胞因子水平升高不足甚至降低。细胞因子网络调节不良可能参与CHF的发生和发展。
