[云南个旧和宣威地区肺癌中人类端粒酶RNA（hTR）的表达]

[Human telomerase RNA (hTR) expression in lung cancer in the Gejiu and Xuanwei regions of Yunnan].

作者信息

Jin K, Gao J, Gao Q, Chen L, Li B, Yang S

机构信息

Department of Pathology, Kunming Medical College, Kunming 650031, China.

出版信息

Zhonghua Bing Li Xue Za Zhi. 2001 Oct;30(5):336-8.

PMID:11769728

Abstract

OBJECTIVE

To investigate the correlation between the expression of hTR in and the pathogenesis of lung cancer in Gejiu and Xuanwei regions of Yunnan province.

METHODS

By use of in situ hybridization, the expression of hTR gene was observed in 81 cases of lung cancer tissues including 24 cases of Gejiu Tin miners (GTM), 36 cases of Xuanwei farmers (XF) and 21 cases of other regions.

RESULTS

hTR was detected in 65.4% (53/81) of the lung cancer cases. The positive rate of hTR in GTM, XF and other regions was 66.7% (16/24), 58.3% (21/36) and 76.2% (16/21) respectively. Positive hTR expression was not found in normal bronchial and alveolar epithelia, but was found in highly proliferating type II alveolar epithelial cells adjacent to the carcinoma (12.3%, 10/81). No significant difference was observed with regard to the positive rate of hTR expression among three different regions. There was no statistically significant correlation between the expression of hTR, the patients' sex, age and the differentiation degree of the tumor, but the expression of hTR was correlated with histological type and lymph node metastasis (P < 0.05).

CONCLUSION

The expression of hTR is a prevailing event in lung cancer and therefore can be used as an indicator of lung malignancy.

摘要

目的

探讨云南省个旧和宣威地区肺癌组织中人端粒酶RNA（hTR）表达与肺癌发生的相关性。

方法

采用原位杂交技术观察81例肺癌组织中人端粒酶RNA基因的表达情况，其中包括24例个旧锡矿矿工肺癌组织（GTM）、36例宣威农民肺癌组织（XF）和21例其他地区肺癌组织。

结果

81例肺癌组织中，hTR阳性表达率为65.4%（53/81）。GTM、XF和其他地区肺癌组织中hTR阳性率分别为66.7%（16/24）、58.3%（21/36）和76.2%（16/21）。正常支气管和肺泡上皮未见hTR阳性表达，在癌旁高度增生的Ⅱ型肺泡上皮细胞中有hTR阳性表达（12.3%，10/81）。不同地区肺癌组织hTR阳性率差异无统计学意义。hTR表达与患者性别、年龄及肿瘤分化程度无关，但与组织学类型及淋巴结转移有关（P<0.05）。