[个旧矿工肺癌组织中TGF-β1表达与其他地区非矿工肺癌组织中TGF-β1表达的比较]
[Comparison of TGF-beta1 expression of lung cancer in Gejiu miners with that in non-miners in other regions].
作者信息
Jiang Ping, Jin Ke-wei, Gao Qian
机构信息
Department of Pathology, Kunming Medical College, Kunming 650031, China.
出版信息
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004 Feb;22(1):36-8.
OBJECTIVE
To investigate the different expression of transforming growth factor beta(1) (TGF-beta(1)) in lung cancer specimens of Gejiu miners, and non-miners in other regions.
METHODS
Thirty specimens of Gejiu miners' lung cancer and 30 specimens of non-miners' were observed in this experiment. The expression of TGF-beta(1) protein and TGF-beta(1) mRNA were detected by the methods of immunohistochemistry and in situ hybridization. The results were quantitatively analyzed using image analysis system.
RESULTS
The positive rate of TGF-beta(1) protein expression in Gejiu miners and non-miners was 75.39%and 44.78% respectively, and the positive rate of TGF-beta(1) mRNA was 63.96% and 34.07% respectively. There were significant differences between the two groups (P < 0.01).
CONCLUSION
The expression of TGF-beta(1) in lung cancer of Gejiu miners was significantly higher than that of non-miners. The pathogenesis of lung cancer may be different between Gejiu miner and non-miners. High expression of TGF-beta(1) may be one of the reasons of high incidence of lung cancer in Gejiu miners.
目的
探讨转化生长因子β(1)（TGF-β(1)）在个旧矿工肺癌标本及其他地区非矿工肺癌标本中的表达差异。
方法
本实验观察了30例个旧矿工肺癌标本和30例非矿工肺癌标本。采用免疫组织化学和原位杂交方法检测TGF-β(1)蛋白和TGF-β(1)mRNA的表达。结果用图像分析系统进行定量分析。
结果
个旧矿工和非矿工中TGF-β(1)蛋白表达阳性率分别为75.39%和44.78%，TGF-β(1)mRNA阳性率分别为63.96%和34.07%。两组间差异有统计学意义（P<0.01）。
结论
个旧矿工肺癌中TGF-β(1)的表达明显高于非矿工。个旧矿工与非矿工肺癌的发病机制可能不同。TGF-β(1)高表达可能是个旧矿工肺癌高发的原因之一。
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