Streit W J
Department of Neuroscience, University of Florida College of Medicine and McKnight Brain Institute, Gainesville 32611, USA.
Neurotoxicology. 2001 Oct;22(5):619-24. doi: 10.1016/s0161-813x(01)00033-x.
An understanding of microglial functions during normal CNS development is prerequisite for understanding developmental neurotoxicology. This review provides a brief summary of previous work regarding the origin of microglia and addresses differences and similarities between microglia and brain macrophages. Current concepts and ideas which implicate microglia in diverse developmental processes, such as apoptosis, axon growth, and vasculogenesis are discussed. The study of reactive microgliosis may prove useful in the histopathological analysis of neurotoxicant-induced brain damage during development.
了解中枢神经系统正常发育过程中的小胶质细胞功能是理解发育神经毒理学的先决条件。本综述简要总结了先前关于小胶质细胞起源的研究工作，并探讨了小胶质细胞与脑巨噬细胞之间的异同。还讨论了涉及小胶质细胞参与多种发育过程（如细胞凋亡、轴突生长和血管生成）的当前概念和观点。反应性小胶质细胞增生的研究可能对发育过程中神经毒物诱导的脑损伤的组织病理学分析有用。
