[布里亚特人群中Alu多态性分析]

[Analysis of Alu-polymorphism in Buryat populations].

作者信息

Khitrinskaia I Iu, Stepanov V A, Pyzyrev V P

机构信息

Institute of Medical Genetics, Tomsk Research Center, Siberian Division, Russian Academy of Medical Sciences, Tomsk, 634050 Russia.

出版信息

Genetika. 2001 Nov;37(11):1553-8.

PMID:11771311

Abstract

Polymorphism of three populations of the Buryat Republic and a population from Aginskii Buryat Autonomous okrug of Chita oblast was examined using a set of five autosomal Alu insertions at the ACE, PLAT, PV92, APOA1, and F13B loci. The allele frequency distribution patterns revealed in Buryat populations were typical to other Asian populations. Buryats were characterized by relatively low level of intrapopulation diversity (0.369 in the pooled population sample). Analysis of autosomal Alu insertions suggests the uniformity of the Buryat gene pool. The coefficient of genetic differentiation in the four populations studied was 0.8%.

摘要

利用位于ACE、PLAT、PV92、APOA1和F13B基因座的一组五个常染色体Alu插入序列，对布里亚特共和国的三个群体以及赤塔州阿金斯基布里亚特自治区的一个群体进行了多态性检测。在布里亚特群体中揭示的等位基因频率分布模式与其他亚洲群体的典型模式相同。布里亚特人的群体内多样性水平相对较低（合并群体样本中为0.369）。对常染色体Alu插入序列的分析表明布里亚特基因库具有一致性。所研究的四个群体中的遗传分化系数为0.8%。