Benabid A L, de Rougemont J, Barge M
J Physiol (Paris). 1975 May;70(1):61-75.
The authors reported previously an elementary mathematical model of intracranial pressure (ICP) as well as result from an experimental verification of the model. The experimental tests revealed that certain factors had been neglected in the theoretical formation, and the present article offers an expanded version of model which takes into account those factors: changes in the formation of the CSF as a function of ICP; cerebral vasomotricity; cortical and sinusal venous pressures, and variations of the filtration coefficient of the subarachnoidal spaces. A generalized mathematical model of ICP, in the form of four equations, is proposed. The major aspects of both normal and pathological ICP are studied in the light of this model, and are integrated into a generalized theory.
作者之前报道了颅内压(ICP)的一个基本数学模型以及该模型的实验验证结果。实验测试表明,在理论构建中某些因素被忽略了,本文提供了一个考虑了这些因素的模型扩展版本:脑脊液生成随颅内压的变化;脑血管舒缩性;皮质和窦静脉压力,以及蛛网膜下腔滤过系数的变化。提出了一个以四个方程形式表示的颅内压广义数学模型。根据该模型研究了正常和病理性颅内压的主要方面,并将其整合到一个广义理论中。