Pujol Jesús, Cardoner Narcís, Benlloch Luisa, Urretavizcaya Mikel, Deus Joan, Losilla Josep M, Capdevila Antoni, Vallejo Julio
Magnetic Resonance Center of Pedralbes, 08950 Barcelona, Spain.
Neuroimage. 2002 Jan;15(1):103-6. doi: 10.1006/nimg.2001.0928.
The Sylvian fissure region gathers lateral frontotemporal cortices and subcortical structures that are frequently disturbed in patients with mood disorders. We have investigated possible CSF space changes in this brain region in severe melancholic depression. Fifty-seven patients and 37 control subjects received three-dimensional MRI. CSF volumes were obtained for cerebral CSF, lateral ventricles, and both Sylvian fissure regions. As a group, patients showed a significant CSF space enlargement that was prominent around the Sylvian fissure, particularly in the left hemisphere. Likewise, evident leftward asymmetry was more frequent in the patient group (patients 31.6%, controls 2.7%). The combination of CSF space enlargement and the pattern of Sylvian CSF asymmetry predicted the patient condition with 62.2% specificity and 82.5% sensitivity. We conclude that, in the context of a broad severity spectrum of imaging alterations in severe melancholic depression, asymmetrical CSF space enlargement may be evident in the Sylvian fissure region.
大脑外侧裂区域汇聚了额叶颞叶外侧皮质和皮质下结构，而这些结构在情绪障碍患者中经常受到干扰。我们研究了重度抑郁性抑郁症患者该脑区脑脊液空间可能存在的变化。57例患者和37例对照受试者接受了三维磁共振成像检查。获取了脑脑脊液、侧脑室和双侧大脑外侧裂区域的脑脊液体积。作为一个整体，患者表现出明显的脑脊液空间扩大，在大脑外侧裂周围尤为突出，特别是在左半球。同样，患者组中明显的左侧不对称更为常见（患者为31.6%，对照为2.7%）。脑脊液空间扩大和大脑外侧裂脑脊液不对称模式相结合，对患者病情的预测特异性为62.2%，敏感性为82.5%。我们得出结论，在重度抑郁性抑郁症广泛严重程度的影像学改变背景下，大脑外侧裂区域可能存在不对称的脑脊液空间扩大。
