Aso M, Suzuki M, Kawasaki Y, Matsui M, Hagino H, Kurokawa K, Seto H, Kurachi M
Department of Neuropsychiatry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Psychiatry Clin Neurosci. 2001 Feb;55(1):49-56. doi: 10.1046/j.1440-1819.2001.00784.x.
Volumes of the medial temporal lobe structures (i.e. the amygdala, hippocampus, and parahippocampal gyrus), Sylvian fissure, and inferior horn of the lateral ventricle relative to the cerebral hemisphere were measured in 24 patients with schizophrenia and 23 normal controls using magnetic resonance imaging. The patients had significantly larger Sylvian fissures and inferior horns bilaterally than the controls. In the patients the right Sylvian fissure size showed a significant positive correlation with the duration of illness. Moreover, earlier onset of illness was significantly correlated with decreased volume of the left medial temporal lobe structures. These results replicate previous finding of inferior horn enlargement and suggest the significance of the Sylvian fissure and the medial temporal lobe structures in pathophysiology of schizophrenia.
利用磁共振成像技术，对24例精神分裂症患者和23名正常对照者的内侧颞叶结构（即杏仁核、海马体和海马旁回）、外侧裂以及侧脑室下角相对于大脑半球的体积进行了测量。患者双侧的外侧裂和下角明显大于对照组。在患者中，右侧外侧裂大小与病程呈显著正相关。此外，发病较早与左侧内侧颞叶结构体积减小显著相关。这些结果重复了之前关于下角增大的发现，并提示外侧裂和内侧颞叶结构在精神分裂症病理生理学中的重要性。
