Cowden E A, Ratcliffe W A, Beastall G H, Ratcliffe J G
Ann Clin Biochem. 1979 May;16(3):113-21. doi: 10.1177/000456327901600126.
The laboratory assessment of prolactin status was evaluated by detailed study of 921 subjects (587 normal subjects and 334 patients with pathological conditions). The effect on serum prolactin levels of age, sex, circadian rhythm, pulsatility of secretion, stress, drug ingestion, and pregnancy was defined in normal subjects. The normal prolactin responses to stimulation (TRH metoclopramide) and suppression (L-dopa, bromocriptine) were also determined. Basal prolactin levels were measured in patients with defined pathological conditions including prolactinoma, idiopathic hyperprolactinaemia, acromegaly, Cushing's disease, chronic renal failure, primary hypothyroidism, pituitary ablation, Kallman's syndrome, Nelson's syndrome, growth hormone deficiency, gonadotrophin deficiency, craniopharyngioma, panhypopituitarism, and chronic progressive arthropathy. Based on these data, a strategy for the routine laboratory assessment of prolactin status is outlined.
通过对921名受试者（587名正常受试者和334名患有病理状况的患者）进行详细研究，评估了催乳素状态的实验室检测情况。在正常受试者中确定了年龄、性别、昼夜节律、分泌脉冲性、压力、药物摄入和妊娠对血清催乳素水平的影响。还测定了对刺激（促甲状腺激素释放激素、甲氧氯普胺）和抑制（左旋多巴、溴隐亭）的正常催乳素反应。对患有特定病理状况的患者进行了基础催乳素水平测量，这些病理状况包括催乳素瘤、特发性高催乳素血症、肢端肥大症、库欣病、慢性肾衰竭、原发性甲状腺功能减退、垂体切除术、卡尔曼综合征、尼尔森综合征、生长激素缺乏、促性腺激素缺乏、颅咽管瘤、全垂体功能减退和慢性进行性关节病。基于这些数据，概述了一种催乳素状态常规实验室评估策略。
