Semple P D, Beastall G H, Brown T M, Stirling K W, Mills R J, Watson W S
Thorax. 1984 Jan;39(1):46-51. doi: 10.1136/thx.39.1.46.
Eight men with hypoxia associated with idiopathic pulmonary fibrosis were studied. Serum testosterone concentrations were low in two subjects and fell to subnormal levels in two others as the clinical condition and arterial oxygen tension deteriorated. There was a significant correlation between serum testosterone concentrations and arterial oxygen tensions (p less than 0.05). Three patients showed evidence of suppression of luteinising hormone secretion at the pituitary level. Only occasional abnormalities of thyroid and prolactin concentrations were noted. Most of the men suffered from organic sexual impotence, which is considered to be due at least in part to endocrine disturbance. These findings are similar to observations in patients with hypoxic chronic obstructive airways disease and support the hypothesis that hypoxia of lung disease suppresses the hypothalamo-pituitary-testicular axis.
对8名患有与特发性肺纤维化相关的低氧血症的男性进行了研究。两名受试者的血清睾酮浓度较低，另外两名受试者的血清睾酮浓度随着临床状况和动脉血氧张力的恶化而降至正常水平以下。血清睾酮浓度与动脉血氧张力之间存在显著相关性（p<0.05）。三名患者显示出垂体水平促黄体生成素分泌受抑制的证据。仅偶尔发现甲状腺和催乳素浓度异常。大多数男性患有器质性性功能障碍，这被认为至少部分归因于内分泌紊乱。这些发现与慢性阻塞性气道疾病低氧血症患者的观察结果相似，并支持以下假设：肺部疾病的低氧血症会抑制下丘脑-垂体-睾丸轴。
