低氧性肺纤维化中的性激素抑制与性功能障碍
Sex hormone suppression and sexual impotence in hypoxic pulmonary fibrosis.
作者信息
Semple P D, Beastall G H, Brown T M, Stirling K W, Mills R J, Watson W S
出版信息
Thorax. 1984 Jan;39(1):46-51. doi: 10.1136/thx.39.1.46.
Abstract
Eight men with hypoxia associated with idiopathic pulmonary fibrosis were studied. Serum testosterone concentrations were low in two subjects and fell to subnormal levels in two others as the clinical condition and arterial oxygen tension deteriorated. There was a significant correlation between serum testosterone concentrations and arterial oxygen tensions (p less than 0.05). Three patients showed evidence of suppression of luteinising hormone secretion at the pituitary level. Only occasional abnormalities of thyroid and prolactin concentrations were noted. Most of the men suffered from organic sexual impotence, which is considered to be due at least in part to endocrine disturbance. These findings are similar to observations in patients with hypoxic chronic obstructive airways disease and support the hypothesis that hypoxia of lung disease suppresses the hypothalamo-pituitary-testicular axis.
摘要
对8名患有与特发性肺纤维化相关的低氧血症的男性进行了研究。两名受试者的血清睾酮浓度较低，另外两名受试者的血清睾酮浓度随着临床状况和动脉血氧张力的恶化而降至正常水平以下。血清睾酮浓度与动脉血氧张力之间存在显著相关性（p<0.05）。三名患者显示出垂体水平促黄体生成素分泌受抑制的证据。仅偶尔发现甲状腺和催乳素浓度异常。大多数男性患有器质性性功能障碍，这被认为至少部分归因于内分泌紊乱。这些发现与慢性阻塞性气道疾病低氧血症患者的观察结果相似，并支持以下假设：肺部疾病的低氧血症会抑制下丘脑-垂体-睾丸轴。
相似文献
1
Sex hormone suppression and sexual impotence in hypoxic pulmonary fibrosis.低氧性肺纤维化中的性激素抑制与性功能障碍
Thorax. 1984 Jan;39(1):46-51. doi: 10.1136/thx.39.1.46.
2
Hypothalamic-pituitary dysfunction in respiratory hypoxia.呼吸性低氧血症中的下丘脑-垂体功能障碍
Thorax. 1981 Aug;36(8):605-9. doi: 10.1136/thx.36.8.605.
3
Reversal of sexual impotence in male patients with chronic obstructive pulmonary disease and hypoxemia with long-term oxygen therapy.
J Steroid Biochem Mol Biol. 1993 Dec;46(6):799-803. doi: 10.1016/0960-0760(93)90321-m.
4
Thyroid function and endocrine abnormalities in elderly patients with severe chronic obstructive lung disease.老年重度慢性阻塞性肺疾病患者的甲状腺功能及内分泌异常
Thorax. 1987 Jul;42(7):520-5. doi: 10.1136/thx.42.7.520.
5
Hypoxia and hypercarbia of chronic lung disease: minimal effects on anterior pituitary function.慢性肺病的低氧血症和高碳酸血症：对垂体前叶功能影响极小。
South Med J. 1990 Mar;83(3):290-3. doi: 10.1097/00007611-199003000-00009.
6
Impact of hypoxaemia on neuroendocrine function and catecholamine secretion in chronic obstructive pulmonary disease (COPD). Effects of long-term oxygen treatment.低氧血症对慢性阻塞性肺疾病（COPD）神经内分泌功能及儿茶酚胺分泌的影响。长期氧疗的作用。
Respir Med. 2000 Dec;94(12):1221-8. doi: 10.1053/rmed.2000.0953.
7
[Endocrine function of the testes, gonadotropic and lactotropic activity of the adenohypophysis in impotence among older men].[老年男性阳痿患者睾丸的内分泌功能、腺垂体促性腺及促乳素活性]
Probl Endokrinol (Mosk). 1986 Mar-Apr;32(2):35-6.
8
Endocrine assessment of impotence--pitfalls of measuring serum testosterone without sex-hormone-binding globulin.阳痿的内分泌评估——不检测性激素结合球蛋白而仅测定血清睾酮的弊端
Postgrad Med J. 1994 Nov;70(829):836-7. doi: 10.1136/pgmj.70.829.836.
9
Gonadal dysfunction in diabetic men with organic impotence.患有器质性阳痿的糖尿病男性的性腺功能障碍
J Clin Endocrinol Metab. 1987 Jul;65(1):127-35. doi: 10.1210/jcem-65-1-127.
10
A study of the endocrine manifestations of hepatic cirrhosis.肝硬化内分泌表现的研究。
Q J Med. 1976 Jan;45(177):145-78.
引用本文的文献
1
Hypoxia exposure impairs male fertility via inhibiting Septin2-mediated spermatogonial proliferation.低氧暴露通过抑制Septin2介导的精原细胞增殖损害雄性生育能力。
Hum Reprod Open. 2025 May 14;2025(3):hoaf027. doi: 10.1093/hropen/hoaf027. eCollection 2025.
2
Gene expression profile analysis of severe influenza-based modulation of idiopathic pulmonary fibrosis.严重流感所致特发性肺纤维化的基因表达谱分析。
Eur J Med Res. 2024 Oct 18;29(1):501. doi: 10.1186/s40001-024-02107-9.
3
Mendelian randomization study reveals the effect of idiopathic pulmonary fibrosis on the risk of erectile dysfunction.孟德尔随机化研究揭示特发性肺纤维化对勃起功能障碍风险的影响。
Front Med (Lausanne). 2023 Jul 12;10:1162153. doi: 10.3389/fmed.2023.1162153. eCollection 2023.
4
Effects of Environmental and Pathological Hypoxia on Male Fertility.环境性和病理性缺氧对男性生育能力的影响。
Front Cell Dev Biol. 2021 Sep 13;9:725933. doi: 10.3389/fcell.2021.725933. eCollection 2021.
5
Obstructive Sleep Apnea Is Associated With Low Testosterone Levels in Severely Obese Men.阻塞性睡眠呼吸暂停与重度肥胖男性的低睾酮水平有关。
Front Endocrinol (Lausanne). 2021 Jul 26;12:622496. doi: 10.3389/fendo.2021.622496. eCollection 2021.
6
Erectile dysfunction is a common problem in interstitial lung diseases.勃起功能障碍是间质性肺疾病中的常见问题。
Sarcoidosis Vasc Diffuse Lung Dis. 2017;34(4):356-364. doi: 10.36141/svdld.v34i4.5692. Epub 2017 Apr 28.
7
Sexual dysfunction in men with COPD: impact on quality of life and survival.男性慢性阻塞性肺疾病患者的性功能障碍：对生活质量和生存率的影响。
Lung. 2012 Oct;190(5):545-56. doi: 10.1007/s00408-012-9398-4. Epub 2012 Jul 3.
8
Genomic approaches in the identification of hypoxia biomarkers in model fish species.利用基因组学方法鉴定模式鱼类中的缺氧生物标志物
J Exp Mar Biol Ecol. 2009 Dec 1;381(Suppl 1):S180-S187. doi: 10.1016/j.jembe.2009.07.021.
9
Obstructive sleep apnea and erectile dysfunction: still a neglected risk factor?阻塞性睡眠呼吸暂停与勃起功能障碍：仍是一个被忽视的风险因素？
Sleep Breath. 2009 Mar;13(1):3-10. doi: 10.1007/s11325-008-0212-8. Epub 2008 Sep 3.
10
Non-genomic effect of testosterone on airway smooth muscle.睾酮对气道平滑肌的非基因组效应。
Br J Pharmacol. 2006 Dec;149(8):1083-91. doi: 10.1038/sj.bjp.0706936. Epub 2006 Oct 30.
本文引用的文献
1
Spirometric studies in normal subjects. II. Ventilatory capacity tests in adults.正常受试者的肺量计研究。II. 成年人的通气能力测试。
Acta Med Scand. 1963 Feb;173:193-8.
2
Clinical usefulness of the single-breath pulmonary diffusing capacity test.单次呼吸肺弥散功能测试的临床应用价值
Am Rev Respir Dis. 1961 Dec;84:789-806. doi: 10.1164/arrd.1961.84.6.789.
3
Seasonal incidence of clinical onset of Hodgkin's disease.霍奇金病临床发病的季节性发病率。
Br Med J. 1961 Sep 2;2(5252):621-3. doi: 10.1136/bmj.2.5252.621.
4
Cyclophosphamide and the prepubertal gonad: a negative report.环磷酰胺与青春期前性腺：一份否定性报告。
J Pediatr. 1974 Jan;84(1):123-5. doi: 10.1016/s0022-3476(74)80572-x.
5
Serum testosterone depression associated with hypoxia in respiratory failure.
Clin Sci (Lond). 1980 Jan;58(1):105-6. doi: 10.1042/cs0580105.
6
Hypothalamic-pituitary dysfunction in respiratory hypoxia.呼吸性低氧血症中的下丘脑-垂体功能障碍
Thorax. 1981 Aug;36(8):605-9. doi: 10.1136/thx.36.8.605.
7
Sexual dysfunction and erectile impotence in chronic obstructive pulmonary disease.慢性阻塞性肺疾病中的性功能障碍与勃起功能障碍
Chest. 1983 Mar;83(3):587-8. doi: 10.1378/chest.83.3.587b.
8
Abnormalities in urinary hormone patterns in lung cancer and emphysema.肺癌和肺气肿患者尿激素模式异常。
Cancer. 1966 Jul;19(7):985-95. doi: 10.1002/1097-0142(196607)19:7<985::aid-cncr2820190712>3.0.co;2-j.
9
Radioimmunoassay of human serum thyrotrophin.人血清促甲状腺素的放射免疫测定
Br Med J. 1971 Mar 13;1(5749):582-5. doi: 10.1136/bmj.1.5749.582.
10
A test of endocrine gonadal function in men: urinary testosterone after the injection of HCG. A different response of the high altitude native.男性性腺内分泌功能测试：注射人绒毛膜促性腺激素后的尿睾酮。高原原住民的不同反应。
J Clin Endocrinol Metab. 1969 Feb;29(2):179-82. doi: 10.1210/jcem-29-2-179.
Zotero 插件