Kahn Jessica A, Rosenthal Susan L, Succop Paul A, Ho Gloria Y F, Burk Robert D
Division of Adolescent Medicine, Children's Hospital Medical Center, Cincinnati, Ohio. Division of Psychology, University of Texas at Galveston, Galveston, Texas, USA.
Pediatrics. 2002 Jan;109(1):E5. doi: 10.1542/peds.109.1.e5.
Previous studies have demonstrated that early age of first sexual intercourse is associated with human papillomavirus (HPV) infection. The objective of this study was to identify a set of risk behaviors and partner characteristics that mediate the association between age of first sexual intercourse and subsequent HPV infection in adolescent and young adult women.
Female university students completed surveys and underwent HPV testing every 6 months for up to 3 years. HPV-positive participants were matched to HPV-negative participants (252 pairs, total N = 504). Associations were examined between risk behaviors/partner characteristics and both age of first sexual intercourse and HPV infection. Those variables associated with either age of first sexual intercourse or HPV infection were entered into a generalized estimating equation (to account for the matched study design) modeling the association between age of first sexual intercourse and HPV infection.
Mean age of first sexual intercourse was 16.7 (+/-1.8) years, and early age of first sexual intercourse was associated significantly with HPV infection (beta = -0.20; odds ratio: 0.82; 95% confidence interval: 0.74-0.90). The association was mediated by number of sexual partners in the past 6 months, history of sexually transmitted infection, alcohol and drug use related to sexual behaviors, and partner's number of sexual partners.
A set of behavioral risk factors and partner characteristics partially mediate the association between age of first sexual intercourse and subsequent HPV infection.
既往研究表明，首次性行为的年龄与人类乳头瘤病毒（HPV）感染有关。本研究的目的是确定一组风险行为和性伴侣特征，这些因素在青少年及年轻成年女性首次性行为的年龄与随后HPV感染之间的关联中起中介作用。
女大学生完成问卷调查，并每6个月接受一次HPV检测，为期3年。HPV阳性参与者与HPV阴性参与者进行匹配（共252对，N = 504）。研究风险行为/性伴侣特征与首次性行为年龄及HPV感染之间的关联。将那些与首次性行为年龄或HPV感染相关的变量纳入广义估计方程（以考虑匹配研究设计），对首次性行为年龄与HPV感染之间的关联进行建模。
首次性行为的平均年龄为16.7（±1.8）岁，首次性行为年龄早与HPV感染显著相关（β = -0.20；比值比：0.82；95%置信区间：0.74 - 0.90）。这种关联由过去6个月内的性伴侣数量、性传播感染史、与性行为相关的酒精和药物使用以及性伴侣的性伴侣数量介导。
一组行为风险因素和性伴侣特征部分介导了首次性行为年龄与随后HPV感染之间的关联。
