Kahn Jessica A, Rosenthal Susan L, Succop Paul A, Ho Gloria Y F, Burk Robert D
Division of Adolescent Medicine, Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
J Pediatr. 2002 Nov;141(5):718-23. doi: 10.1067/mpd.2002.128893.
We sought to determine whether the interval between menarche and age of first sexual intercourse is associated with subsequent human papilloma virus (HPV) infection and if so, whether the association is independent of the age of first sexual intercourse. Female university students completed a survey and were screened for cervicovaginal HPV infection. HPV-positive subjects were matched to HPV-negative subjects (n = 504). Mean subject age was 20.4 +/- 2.1 years, age of first sexual intercourse 16.7 +/- 1.8 years, and interval 4.4 +/- 2.0 years. The interval was associated with HPV infection, but the association became nonsignificant in univariate stratified analyses and multivariate models estimating the association between the interval and HPV infection. A short interval is associated with HPV infection, but the association is not independent of age of first sexual intercourse. Age of first sexual intercourse should be considered an important and identifiable risk factor for subsequent HPV infection in research and clinical settings.
我们试图确定月经初潮与首次性行为年龄之间的间隔是否与随后的人乳头瘤病毒（HPV）感染相关，如果是，这种关联是否独立于首次性行为年龄。女大学生完成了一项调查，并接受了宫颈阴道HPV感染筛查。HPV阳性受试者与HPV阴性受试者进行匹配（n = 504）。受试者平均年龄为20.4±2.1岁，首次性行为年龄为16.7±1.8岁，间隔为4.4±2.0年。该间隔与HPV感染相关，但在单变量分层分析和估计该间隔与HPV感染之间关联的多变量模型中，这种关联变得不显著。较短的间隔与HPV感染相关，但这种关联并非独立于首次性行为年龄。在研究和临床环境中，首次性行为年龄应被视为随后HPV感染的一个重要且可识别的风险因素。
