Malinsky M, Laurent M F, Daninos J M, Kadouche J, Brisson C
Ann Endocrinol (Paris). 1979 Jul-Aug;40(4):419-20.
The level of TBG in normal adults is 2.21 +/- 0.4 mg/100 ml, without any sex difference. TBG levels are high in the neonatal period (3.26 +/- 0.49 mg/100 ml) and in children under the age of 1 year (2.61 +/- 0.66 mg). Estrogens induce a significant increase (3.96 +/- 1.0 mg) and corticoids a significant decrease of TBG (1.44 +/- 0.32 mg). TBG is also decreased in thyrotoxicosis (1.88 +/- 0.34 mg) but normal in hypothyroidism. There is a strong correlation between T4 and TBG levels, and the T4/TBG ratio appears to be a useful index, which remains constant in normal adults, and under treatment by estrogens and corticoids.
正常成年人的甲状腺结合球蛋白（TBG）水平为2.21±0.4mg/100ml，无性别差异。新生儿期（3.26±0.49mg/100ml）和1岁以下儿童（2.61±0.66mg）的TBG水平较高。雌激素可使其显著升高（3.96±1.0mg），而皮质激素则使其显著降低（1.44±0.32mg）。甲状腺毒症时TBG也降低（1.88±0.34mg），但甲状腺功能减退时正常。T4与TBG水平之间存在强相关性，T4/TBG比值似乎是一个有用的指标，在正常成年人以及接受雌激素和皮质激素治疗时保持恒定。
