Konno N, Kakinoki A, Miura K, Hagiwara K, Taguchi H, Minami R
Clin Endocrinol (Oxf). 1985 Mar;22(3):249-55. doi: 10.1111/j.1365-2265.1985.tb03237.x.
The concentration of serum thyroxine (T4)-binding globulin (TBG) not binding T4 (unsaturated TBG, u-TBG) was determined in hyper- and hypothyroidism. u-TBG was expressed as the product of TBG concentration and the ratio of free TBG capacity to maximal TBG capacity as determined by reverse-flow electrophoresis. u-TBG concentration in normal sera (n = 40) was 15.5 +/- 2.3 mg/l (mean +/- SD), or 257 +/- 38 nmol/l for a molecular weight of TBG of 60 000 daltons. u-TBG levels were significantly lower in hyperthyroidism (7.1 +/- 2.3 mg/l, n = 16, P less than 0.001) and higher in hypothyroidism (21.7 +/- 5.0 mg/l, n = 22, P less than 0.001). Based on partial correlation analysis, u-TBG was inversely correlated to serum T4 (r = -0.586, P less than 0.001), but not correlated to triiodothyronine (T3) (r=-0.180, NS). There was a reciprocal correlation between u-TBG concentration and the T3 uptake value (r = 0.748, P less than 0.001). There was also a reciprocal correlation of u-TBG with both % free T4 (r = 0.425, P less than 0.001) and % free T3 (r = 0.377, P less than 0.001), when the data were subjected to partial correlation analysis. These results provide the values for u-TBG concentration in hyper- and hypothyroidism, and support the concept that the free fractions of serum thyroid hormones may be determined by the number of binding sites of the TBG molecule that are not saturated with T4 in hyper-and hypothyroidism.
测定了甲状腺功能亢进和减退患者血清中未结合甲状腺素（T4）的甲状腺素结合球蛋白（TBG）（不饱和TBG，u-TBG）浓度。u-TBG通过TBG浓度与反流电泳测定的游离TBG容量与最大TBG容量之比的乘积来表示。正常血清（n = 40）中u-TBG浓度为15.5±2.3mg/l（均值±标准差），对于分子量为60000道尔顿的TBG，相当于257±38nmol/l。甲状腺功能亢进患者的u-TBG水平显著降低（7.1±2.3mg/l，n = 16，P＜0.001），甲状腺功能减退患者的u-TBG水平则升高（21.7±5.0mg/l，n = 22，P＜0.001）。基于偏相关分析，u-TBG与血清T4呈负相关（r = -0.586，P＜0.001），但与三碘甲状腺原氨酸（T3）无相关性（r = -0.180，无显著性差异）。u-TBG浓度与T3摄取值呈负相关（r = 0.748，P＜0.001）。对数据进行偏相关分析时，u-TBG与游离T4百分比（r = 0.425，P＜0.001）和游离T3百分比（r =
