Mountokalakis T, Merikas G, Skipelitis P, Vardakis M, Sevastos N, Alivisatos J
Klin Wochenschr. 1975 Jul 1;53(13):633-5. doi: 10.1007/BF01469684.
Spironolactone, 200 mg/24 hours, was administered for 4 days to 18 clinically healthy subjects and 10 hospitalised patients with normal renal function. Changes of fractional renal clearance of magnesium before and after spironolactone administration were studied in the first group. Corresponding changes of the ratio of renal clearance of potassium to renal clearance of magnesium were studied in the second group. After spironolactone administration, fractional clearance of magnesium showed a statistically significant decrease in relation to its values before spironolactone administration, while the ratio clearance of potassium/clearance of magnesium showed no statistically significant change. The results suggest that spironolactone administration decreases the renal excretion of magnesium and potassium in an equivalent manner.
对18名临床健康受试者和10名肾功能正常的住院患者给予螺内酯，剂量为200毫克/24小时，持续4天。第一组研究了服用螺内酯前后镁的肾清除分数变化。第二组研究了钾的肾清除率与镁的肾清除率之比的相应变化。服用螺内酯后，镁的清除分数相对于服用螺内酯前的值有统计学意义的下降，而钾清除率/镁清除率之比无统计学意义的变化。结果表明，服用螺内酯以同等方式减少镁和钾的肾脏排泄。
