[一氧化氮合酶在舌鳞状细胞癌中的表达及其预后]
[Expression of nitric oxide synthase in squamous cell carcinoma of tongue and its prognosis].
作者信息
Chen W, Li H, Pan C
机构信息
Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510120.
出版信息
Zhonghua Kou Qiang Yi Xue Za Zhi. 1998 May;33(3):152-4.
OBJECTIVE
To study the expression of nitric oxide synthase (NOS) in squamous cell carcinoma of tongue and its prognosis.
METHODS
The NOSI, NOSII and NOSIII of 55 cases of squamous cell carcinoma of tongue were detected by immunohistochemistry.
RESULTS
The expressive rates of NOSI, NOSII and NOSIII were 30.9%, 40.0% and 38.2% respectively. There were significant differences between the patients with and without neck nodal metastasis, and between the patients survival more than 5 years and less than 5 years (P < 0.01), There were differences between G1, G2 and G3 and the clinical stages in NOSII (P < 0.05).
CONCLUSION
The expression of the NOSI, NOSII and NOSIII in squamous cell carcinoma of tongue is raleted to its prognosis and the NOSII plays a more important role in growth, differentiation, metastatic capability and prognosis of the tumor.
目的
研究一氧化氮合酶（NOS）在舌鳞状细胞癌中的表达及其预后情况。
方法
采用免疫组织化学法检测55例舌鳞状细胞癌组织中NOSI、NOSII和NOSIII的表达。
结果
NOSI、NOSII和NOSIII的表达率分别为30.9%、40.0%和38.2%。有、无颈部淋巴结转移患者之间以及生存5年以上和5年以下患者之间差异有统计学意义（P<0.01）；NOSII在G1、G2和G3及临床分期之间差异有统计学意义（P<0.05）。
结论
舌鳞状细胞癌中NOSI、NOSII和NOSIII的表达与预后有关，NOSII在肿瘤的生长、分化、转移能力及预后方面起更重要作用。
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