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[诱导型一氧化氮合酶mRNA在舌鳞状细胞癌中的表达]

[Expression of inducible nitric oxide synthase mRNA in squamous cell carcinoma of tongue].

作者信息

Chen Wei-liang, Zeng Shu-guang, Li Hai-gang, Huang Hong-zhang, Pan Chao-bing

机构信息

Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, P. R. China.

出版信息

Ai Zheng. 2002 Mar;21(3):314-8.

PMID:12452003
Abstract

BACKGROUND & OBJECTIVE: Recently, most of studies have indicated that nitric oxide (NO) plays an important role in carcinogenesis and tumor progression. Inducible nitric oxide synthase(iNOS) has been found at significantly higher expression levels in head and neck squamous cell carcinoma (HNSCCA) specimens as compared with that in normal tissue. Furthermore, these data provided strong evidance for the role of iNOS generating NO in HNSCCA progression. However, there was no report about whether expression of iNOS mRNA in oral carcinoma is associated with its biological behavior. This study was designed to investigate the correlation between expression of inducible nitric oxide synthase mRNA (iNOS mRNA) in squamous cell carcinoma of tongue tissue and its invasive growth, neck lymph node metastasis, and prognosis.

METHODS

Sixty-eight cases with squamous cell carcinoma of tongue tissues were investigated. All cases with tongue carcinoma were followed up to obtain the information of prognosis. In situ hybridization assay was used to detect the expression of iNOS mRNA in tongue carcinoma tissues. The correlation between expression of iNOS mRNA in squamous cell carcinoma of tongue tissue and its invasive growth, neck lymph node metastasis, and prognosis was analyzed.

RESULTS

  1. The positive expression rate of iNOS mRNA was 86.1% and 48.0% in the group of invasive growth and no invasive growth respectively. The difference between the two groups was significant with coefficient of 0.3. 2. The positive expression rate of iNOS mRNA was 85.7% and 62.5% in the group of positive lymph node metastasis and negative lymph node metastasis respectively. The difference between the two groups was significant, which the correlation coefficient was 0.3. 3. Three-year survival rate was significantly lower in the group of positive expression of iNOS mRNA than that in the group of negative expression of iNOS mRNA in the tongue carcinoma.

CONCLUSIONS

  1. A positive correlation was found between the positive expression of iNOS mRNA and invasive growth as well as neck lymph node metastatsis of squamous cell carcinoma of tongue. 2. The patient's prognosis of the positive expression of iNOS mRNA would be worse than that of the negative expression of iNOS mRNA in tongue carcinoma tissue.
摘要

背景与目的

近年来，大多数研究表明一氧化氮（NO）在肿瘤发生和肿瘤进展中发挥重要作用。与正常组织相比，头颈部鳞状细胞癌（HNSCCA）标本中诱导型一氧化氮合酶（iNOS）的表达水平显著更高。此外，这些数据为iNOS产生的NO在HNSCCA进展中的作用提供了有力证据。然而，关于口腔癌中iNOS mRNA的表达是否与其生物学行为相关尚无报道。本研究旨在探讨舌组织鳞状细胞癌中诱导型一氧化氮合酶mRNA（iNOS mRNA）的表达与其侵袭性生长、颈部淋巴结转移及预后之间的相关性。

方法

对68例舌组织鳞状细胞癌患者进行研究。对所有舌癌患者进行随访以获取预后信息。采用原位杂交法检测舌癌组织中iNOS mRNA的表达。分析舌组织鳞状细胞癌中iNOS mRNA的表达与其侵袭性生长、颈部淋巴结转移及预后之间的相关性。

结果

  1. iNOS mRNA在侵袭性生长组和无侵袭性生长组的阳性表达率分别为86.1%和48.0%。两组间差异有统计学意义，系数为0.3。2. iNOS mRNA在阳性淋巴结转移组和阴性淋巴结转移组的阳性表达率分别为85.7%和62.5%。两组间差异有统计学意义，相关系数为0.3。3. 舌癌中iNOS mRNA阳性表达组的3年生存率显著低于iNOS mRNA阴性表达组。

结论

  1. 舌鳞状细胞癌中iNOS mRNA的阳性表达与侵袭性生长及颈部淋巴结转移呈正相关。2. 舌癌组织中iNOS mRNA阳性表达患者的预后比iNOS mRNA阴性表达患者差。

相似文献

1
[Expression of inducible nitric oxide synthase mRNA in squamous cell carcinoma of tongue].[诱导型一氧化氮合酶mRNA在舌鳞状细胞癌中的表达]
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2
Increased expression of inducible nitric oxide synthase for human buccal squamous-cell carcinomas: immunohistochemical, reverse transcription-polymerase chain reaction (RT-PCR) and in situ RT-PCR studies.人颊部鳞状细胞癌中诱导型一氧化氮合酶表达增加：免疫组织化学、逆转录聚合酶链反应（RT-PCR）及原位RT-PCR研究
Head Neck. 2002 Oct;24(10):925-32. doi: 10.1002/hed.10131.
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Biomed Res Int. 2015;2015:637853. doi: 10.1155/2015/637853. Epub 2015 Oct 7.
2
Expression of inducible nitric oxide synthase in carcinomas and sarcomas affecting the oral cavity.诱导型一氧化氮合酶在影响口腔的癌和肉瘤中的表达。
South Asian J Cancer. 2015 Apr-Jun;4(2):78-82. doi: 10.4103/2278-330X.155686.
3
Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma.
口腔鳞状细胞癌组织学正常边缘中一氧化氮合酶2（NOS2）的表达
Med Oral Patol Oral Cir Bucal. 2014 May 1;19(3):e242-7. doi: 10.4317/medoral.19351.