Gagliardino J J, de la Hera M, Siri F
Centro de Endocrinología Experimental y Aplicada (CENEXA), Universidad Nacional de La Plata-Consejo Nacional de Investigaciones Científicas y Técnicas (UNLP-CQNICET), La Plata, Argentina.
Rev Panam Salud Publica. 2001 Nov;10(5):309-17. doi: 10.1590/s1020-49892001001100003.
To make a preliminary diagnosis of the quality of care that individuals with diabetes mellitus (DM) received in participating centers of the QUALIDIAB network in Latin America and the Caribbean, and to assess the potential usefulness of this information as well as the importance of expanding the QUALIDIAB network.
A total of 13,513 patient records from the QUALIDIAB network were analyzed, from public and private health care entities and from the Social Security systems of Argentina, Brazil, Chile, Colombia, Paraguay, and Uruguay. The study utilized: 1) quality-of-care indicators based on international reference values, 2) patient information on clinical, biochemical, and therapeutic parameters and on the rate of use of diagnostic and therapeutic materials, 3) a computer database program, and 4) a software program for statistical analysis.
Among the patients studied, about half of them had suffered from diabetes for 5 years or less; this was true both for persons with type 1 diabetes (DM1) and for those with type 2 diabetes (DM2). Of the persons with DM1, 24% of them had a blood glucose level of < 4.4 mmol/L; this was true for 15% of those with DM2. The proportion of persons with a blood glucose level of > 7.7 mmol/L was 41% among those with DM1 and 57% among those with DM2. The frequencies of association between DM2 and other cardiovascular risk factors were: overweight/obesity, 59%; hypertension, 60%; total cholesterol > 5.5 mmol/L, 53%; high-density lipoprotein cholesterol < 1 mmol/L, 32%; triglycerides > 1.7 mmol/L, 45%; and smoking, 13%. Of the people with DM1, 20% of them had a body mass index < 19 kg/m2, probably reflecting deficient metabolic control and inadequate insulin intake. The systematic checking of metabolic control, other cardiovascular risk factors, and chronic DM complications was inadequate in from 3% to 75% of the cases, depending on the specific aspect considered. According to various patient-therapy-education indicators, only some one-quarter to one-half of the studied patients could play an active, effective role in DM control and treatment. Of the persons with DM1, 50% of them were treated with a mixed dose of insulin (NPH + regular insulin), administered in two daily injections in 43% of the cases. Among the patients, 5% of them received one daily insulin injection, and 9% of them received three daily insulin injections. Of the people with DM2, 13% of them treated it only with diet and 14% just with insulin. Among the patients receiving drug treatment, the oral hypoglycemics most used in monotherapy were sulfonylureas (33%), biguanides (9%), and a combination of these two (14%). Fewer than half of the people with diabetes received drug therapy for the associated cardiovascular risk factors. The frequency of patients' macroangiopathic and microangiopathic complications increased with the duration of their disease. Comparing patients who had had diabetes for 5 years or less with those who had had the illness for more than 20 years, the frequency of renal insufficiency and of amputations was around 7 times as great in the latter group; for peripheral neuropathy, it was 2 times as great, and for stroke 1.6 times as great.
These results show the need to improve the quality of care for diabetic patients in Latin America and the Caribbean, and that QUALIDIAB could help do this. Expanding the QUALIDIAB network will help to more accurately diagnose the quality of that care in the Americas, and it will facilitate interventions aimed at optimizing the care. This, in turn, will improve the quality of life of persons who suffer from diabetes as well as diminish the socioeconomic costs of the disease.
对拉丁美洲和加勒比地区QUALIDIAB网络参与中心的糖尿病患者所接受的医疗服务质量进行初步诊断,并评估这些信息的潜在用途以及扩大QUALIDIAB网络的重要性。
分析了QUALIDIAB网络中来自阿根廷、巴西、智利、哥伦比亚、巴拉圭和乌拉圭的公共和私立医疗保健机构以及社会保障系统的总共13513份患者记录。该研究采用了:1)基于国际参考值的医疗质量指标;2)有关临床、生化和治疗参数以及诊断和治疗材料使用比例的患者信息;3)计算机数据库程序;4)用于统计分析的软件程序。
在所研究的患者中,约一半患有糖尿病5年或更短时间;1型糖尿病(DM1)患者和2型糖尿病(DM2)患者均如此。在DM1患者中,24%的患者血糖水平<4.4 mmol/L;DM2患者中这一比例为15%。血糖水平>7.7 mmol/L的患者比例在DM1患者中为41%,在DM2患者中为57%。DM2与其他心血管危险因素之间的关联频率分别为:超重/肥胖59%;高血压60%;总胆固醇>5.5 mmol/L 53%;高密度脂蛋白胆固醇<1 mmol/L 32%;甘油三酯>1.7 mmol/L 45%;吸烟13%。在DM1患者中,20%的患者体重指数<19 kg/m2,这可能反映了代谢控制不足和胰岛素摄入不足。根据所考虑的具体方面,在3%至75%的病例中,对代谢控制、其他心血管危险因素和慢性糖尿病并发症的系统检查不足。根据各种患者-治疗-教育指标,在所研究的患者中,只有约四分之一至二分之一的患者能够在糖尿病控制和治疗中发挥积极、有效的作用。在DM1患者中,50%的患者接受中效胰岛素与正规胰岛素混合剂量治疗,43%的病例为每日两次注射。在患者中,5%的患者每日注射一次胰岛素,9%的患者每日注射三次胰岛素。在DM2患者中,13%的患者仅通过饮食治疗,14%的患者仅使用胰岛素治疗。在接受药物治疗的患者中,单药治疗最常用的口服降糖药为磺脲类(33%)、双胍类(9%)以及两者联用(14%)。不到一半的糖尿病患者接受了针对相关心血管危险因素的药物治疗。患者的大血管和微血管并发症发生率随病程延长而增加。将患糖尿病5年或更短时间的患者与患病超过20年的患者进行比较,后一组患者的肾功能不全和截肢发生率约为前一组的7倍;外周神经病变发生率为2倍,中风发生率为1.6倍。
这些结果表明拉丁美洲和加勒比地区需要改善糖尿病患者的医疗服务质量,且QUALIDIAB有助于实现这一目标。扩大QUALIDIAB网络将有助于更准确地诊断美洲地区的医疗服务质量,并促进旨在优化医疗服务的干预措施。反过来,这将改善糖尿病患者的生活质量,并降低该疾病的社会经济成本。