Markham R J, Wilkie B N
Arch Environ Health. 1979 Nov-Dec;34(6):418-23. doi: 10.1080/00039896.1979.10667443.
Adddition of an anionic detergent to aerosols of Bacillus subtilis protease markedly increased mortality in guinea pigs following a single aerosol exposure and altered the nature of the lung pathology after exposure. It was observed that the detergent inhibited in vitro activity of serum protease inhibitors and it is suggested that such impairment may be, in part, responsible for the observed in vivo effects of detergent on protease-induced mortality and pulmonary pathology.
向枯草芽孢杆菌蛋白酶气溶胶中添加阴离子洗涤剂，在单次气溶胶暴露后显著增加了豚鼠的死亡率，并改变了暴露后肺部病理的性质。据观察，该洗涤剂抑制了血清蛋白酶抑制剂的体外活性，有人认为这种损害可能部分导致了洗涤剂对蛋白酶诱导的死亡率和肺部病理的体内观察到的影响。
