Markham R J, Wilkie B N
Int Arch Allergy Appl Immunol. 1976;51(5):529-43. doi: 10.1159/000231627.
An anionic detergent, sodiumdodecylbenzenesulphonate, had an adjuvant effect upon aerosol allergic sensitization with subtilopeptidase A, a proteolytic enzyme of Bacillus subtilis. Both local and systemic antibody responses were accelerated and prolonged by use of the detergent. This adjuvant effect was only seen when an inactive form of the enzyme was used. The detergent, however, was able to potentiate early clinical responses upon initial exposure to the active enzyme.
一种阴离子洗涤剂——十二烷基苯磺酸钠，对用枯草杆菌蛋白酶A（枯草芽孢杆菌的一种蛋白水解酶）进行气溶胶过敏致敏具有佐剂作用。使用该洗涤剂可加速并延长局部和全身抗体反应。只有当使用酶的无活性形式时才会出现这种佐剂效应。然而，该洗涤剂能够增强初次接触活性酶时的早期临床反应。
