De Sanctis M T, Cesarone M R, Incandela L, Belcaro G, Griffin M
Irvine2 Vascular Laboratory, Department of Biomedical Sciences, Chieti University and San Valentino Vascular Screening Project, Italy.
Angiology. 2001 Dec;52 Suppl 3:S63-7. doi: 10.1177/0003319701052003S12.
The aim of this randomized, placebo-controlled study was to evaluate the effect of local treatment with Essaven gel (EG), in comparison with placebo and with a group of controls in 23 patients with superficial vein thrombophlebitis (SVTPH) of the arms. SVTPH was consequent to infusional treatment with an intravenous catheter. The 4-week study evaluated the average skin temperature and an analogue symptomatic score. In patients treated with active EG, the decrease in score and in composite skin temperature was significantly larger than in the placebo and control groups. No intolerance was observed. The decrease in score and temperature in the placebo group was mainly due to skin manipulation and massage and to spontaneous resolution. In conclusion treatment with EG in arm SVTPH improves signs /symptoms and decreases skin temperature faster. This study confirms earlier observations on the effective, local use of EG in SVTPH.
这项随机、安慰剂对照研究的目的是评估Essaven凝胶（EG）局部治疗的效果，并与安慰剂以及一组患有手臂浅静脉血栓性静脉炎（SVTPH）的23名患者组成的对照组进行比较。SVTPH是静脉导管输注治疗的结果。为期4周的研究评估了平均皮肤温度和类似症状评分。在接受活性EG治疗的患者中，评分和复合皮肤温度的下降明显大于安慰剂组和对照组。未观察到不耐受情况。安慰剂组评分和温度的下降主要归因于皮肤操作和按摩以及自行缓解。总之，EG治疗手臂SVTPH可更快改善体征/症状并降低皮肤温度。本研究证实了先前关于EG在SVTPH中有效局部应用的观察结果。
