Yang X, Wu Z, Wang C, Li Y, Liu Z, Tang J, Sun Y, Zhang Y, Yin K
Beijing Neurosurgical Institute, Beijing 100050, China.
Chin Med J (Engl). 2000 Oct;113(10):921-6.
To develop a Chinese-made electrolytic detachable coil (CEDC) that would allow patients to enjoy the benefit of electrolytic detachable coil without having to rely on the expensive Guglielmi detachable coil (GDC), and to test the safety and efficiency of CEDC.
Radiopacity of the marker of the CEDC was tested. The anti-strain force of coils and connection points were measured. In vitro and in vivo electrolyses were conducted. We produced 21 aneurysm models including lateral, bifurcation, and terminal aneurysm models, and embolized 18 models with CEDC.
Radiopacity of the marker was satisfactory. Anti-strain of the coil and the connection point have shown the safety and efficiency of CEDC. Electrolysis in vitro and vivo, was similar to that of GDC. 83% of the aneurysm models were completely occluded. Coils were found to induce thrombosis in the aneurysm cavity, and could lead to a new endothelium over the entrance of the aneurysm, with organized tissue replacing thrombosis in 2 months.
CEDC is as efficient and safe as GDC. The marker, the ability to induce thrombosis inside the sac and the growth of new endothelium over the orifice are very satisfactory.
研发一种国产电解可脱卸弹簧圈（CEDC），使患者无需依赖昂贵的 Guglielmi 可脱卸弹簧圈（GDC）就能享受到电解可脱卸弹簧圈的益处，并测试 CEDC 的安全性和有效性。
测试 CEDC 标记物的显影性。测量弹簧圈及连接点的抗应变力。进行体外和体内电解。制作 21 个动脉瘤模型，包括侧方、分叉和末端动脉瘤模型，并用 CEDC 栓塞其中 18 个模型。
标记物的显影性良好。弹簧圈及连接点的抗应变力表明了 CEDC 的安全性和有效性。体外和体内电解与 GDC 相似。83%的动脉瘤模型实现完全闭塞。发现弹簧圈可在动脉瘤腔内诱发血栓形成，并可导致动脉瘤入口处形成新的内皮，2 个月内有组织的组织取代血栓。
CEDC 与 GDC 一样有效且安全。其标记物、在瘤腔内诱发血栓形成的能力以及瘤口处新内皮的生长情况都非常令人满意。
