Liu N, Wang C, Shao Y
Department of Surgery, Cancer Institute (Hospital), Chinese Academic of Medical Sciences, Peking Union Medical College, Beijing 100021, China.
Zhonghua Zhong Liu Za Zhi. 2000 Jan;22(1):64-6.
To better understand the clinical and pathological features, diagnosis, treatment and prognosis of Paget's disease accompanying breast cancer.
From 1958 to 1997, 34 such patients were operated and pathologically confirmed.
Breast cancer combined with Pagat's disease accounted for 0.9% of the total number of breast cancer patients treated in the same period of time. The mean age of patients was 47.3 years, and the mean duration of symptoms was 23.9 months. The patients received combination treatment with surgery as the major treatment modality. Among patients with nipple change as the first symptom, 26.7% of them had positive axillary nodes. The rate of metastasis was 26.7% as confirmed by surgical pathology. The 5-, 10-, and 20-year survival rate was 93.1%, 78.1% and 67.0%, respectively. Among those with palpable mass as the first symptom, metastasis to the axillary lymph nodes occurred in 52.6% of the cases, and distant metastasis in 42.1% of the cases. The rate of 5-, 10- and 20-year survival rate was 60.5%, 53.8% and 53.8%, respectively.
Paget's disease, as a special form of breast cancer, may accompany cancer inside of the breast. In patients whose disease is confined to the nipple, their prognosis is better than those accompanied by palpable mass in the breast.
更好地了解伴发乳腺癌的佩吉特病的临床病理特征、诊断、治疗及预后。
1958年至1997年，对34例此类患者进行手术并经病理确诊。
乳腺癌合并佩吉特病占同期收治乳腺癌患者总数的0.9%。患者平均年龄47.3岁，平均症状持续时间23.9个月。患者接受以手术为主的综合治疗。以乳头改变为首发症状的患者中，26.7%腋窝淋巴结阳性。经手术病理证实转移率为26.7%。5年、10年和20年生存率分别为93.1%、78.1%和67.0%。以可触及肿块为首发症状的患者中，52.6%发生腋窝淋巴结转移，42.1%发生远处转移。5年、10年和20年生存率分别为60.5%、53.8%和53.8%。
佩吉特病作为乳腺癌的一种特殊形式，可能伴有乳腺内癌。病变局限于乳头的患者，其预后优于伴有乳腺可触及肿块的患者。
