Wang S, Zhang F, Duanmu H
Tuberculosis Control Center, Ministry of Public Health, China, Beijing 101149.
Zhonghua Jie He He Hu Xi Za Zhi. 1999 Dec;22(12):728-30.
To establish the surveillance system for drug resistance of tuberculosis according to WHO and IUATLD guidelines, and to evaluate the initial and acquired drug resistance in Shandong province.
30 of 141 counties/cities were randomly selected as surveillance points by cluster sampling from April to October 1997, in each of which 36 cases with smear positive pulmonary tuberculosis were continuously observed. Identification and susceptibility tests were done in all culture positive samples.
The total frequency of drug resistance was 23.4%, initial drug resistance 17.6%, initial multi-drug resistance 2.9%, acquired drug resistance 50.0%, acquired multi-drug resistance 19.6%.
The results suggest that the initial drug resistance still ranks high in Shandong province, National TB Control Program should be further strengthened.
根据世界卫生组织（WHO）和国际防痨和肺部疾病联盟（IUATLD）的指南建立结核病耐药监测系统，评估山东省结核病的初始耐药和获得性耐药情况。
1997年4月至10月，采用整群抽样法从141个县/市中随机抽取30个作为监测点，每个监测点连续观察36例痰涂片阳性的肺结核患者。对所有培养阳性的样本进行鉴定和药敏试验。
总耐药率为23.4%，初始耐药率为17.6%，初始耐多药率为2.9%，获得性耐药率为50.0%，获得性耐多药率为19.6%。
结果表明山东省初始耐药率仍然较高，国家结核病控制规划应进一步加强。
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