中国山东省耐利福平结核分枝杆菌分离株的rpoB基因突变及分子特征
rpoB Gene mutations and molecular characterization of rifampin-resistant Mycobacterium tuberculosis isolates from Shandong Province, China.
作者信息
Ma Xin, Wang Haiying, Deng Yunfeng, Liu Zhimin, Xu Yong, Pan Xi, Musser James M, Graviss Edward A
机构信息
Kathearine Hsu Internation REsearch Center of Human Infectious Diseases, Shandong Provinical Tuberculosis Control Center, Jinan, Shandong, China.
出版信息
J Clin Microbiol. 2006 Sep;44(9):3409-12. doi: 10.1128/JCM.00515-06.
Abstract
Sixty rifampin (RIF)-resistant and 75 RIF-susceptible Mycobacterium tuberculosis isolates from Shandong Province, China, were analyzed for rpoB gene mutations and genotyped. Mycobacterial interspersed repetitive unit (MIRU) genotype 223325173533 was overrepresented among RIF-resistant isolates. MIRU combined with IS6110 restriction fragment length polymorphism analysis as the second-line genotyping method may reflect epidemiologic links more reliably than each method alone.
摘要
对来自中国山东省的60株耐利福平（RIF）和75株对利福平敏感的结核分枝杆菌分离株进行了rpoB基因突变分析和基因分型。耐利福平分离株中，分枝杆菌散布重复单位（MIRU）基因型223325173533的比例过高。与单独使用每种方法相比，MIRU联合IS6110限制性片段长度多态性分析作为二线基因分型方法可能更可靠地反映流行病学联系。
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