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与法属圭亚那的类似人群相比,加蓬偏远地区人群中HTLV-I的高变异性。

High variability of HTLV-I in a remote population of Gabon as compared to that of a similar population of French Guiana.

作者信息

Moynet D, Pouliquen J F, Londos-Gagliardi D, Buigues R P, Moreau J F, Bedjabaga I, Georges M C, Talarmin A, Joubert M, Fleury H, Vincendeau P, Guillemain B

机构信息

Immunologie Moléculaire et Parasitologie, Université Bordeaux2, France.

出版信息

Virus Genes. 2001 Dec;23(3):257-61. doi: 10.1023/a:1012513121028.

Abstract

An anomalous high frequency of ATL was observed in a remote 'noir maroons' village of French Guiana. Since it is not clear if HTLV-I is responsible for different frequencies of disease in different geographical areas, we undertook a comparison of the population with a similar one located in Gabon. We found a much higher degree of gp46 surface envelope glycoprotein sequence conservation in the Guianese village than in the Gabonese one.

摘要

在法属圭亚那一个偏远的“黑色逃亡黑奴”村庄中观察到成人T细胞白血病/淋巴瘤(ATL)出现异常高的发病率。由于尚不清楚人类嗜T淋巴细胞病毒I型(HTLV-I)是否是导致不同地理区域疾病发病率差异的原因,我们对法属圭亚那的人群与加蓬的类似人群进行了比较。我们发现,与加蓬的村庄相比,法属圭亚那村庄中gp46表面包膜糖蛋白序列的保守程度要高得多。

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