强迫性梳理行为的遗传基础。

A genetic basis for obsessive grooming.

作者信息

Graybiel Ann M, Saka Esen

机构信息

Department of Brain and Cognitive Sciences and the McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

出版信息

Neuron. 2002 Jan 3;33(1):1-2. doi: 10.1016/s0896-6273(01)00575-x.

DOI:10.1016/s0896-6273(01)00575-x

PMID:11779470

Abstract

Excessive grooming behaviors, cleansing rituals, and self-mutilation are important features of a range of neuropsychiatric diseases including obsessive compulsive (OC)-spectrum disorders. In this issue of Neuron, Greer and Capecchi (2002) report that Hoxb8 mutant mice exhibit this behavioral phenotype. These Hoxb8 mutants will be valuable in exploring the genetics and pathophysiology of OC-spectrum disorders as well as strategies for their treatment.

摘要

过度梳理行为、清洁仪式和自我伤害是包括强迫症（OC）谱系障碍在内的一系列神经精神疾病的重要特征。在本期《神经元》杂志中，格里尔和卡佩奇（2002年）报告称，Hoxb8突变小鼠表现出这种行为表型。这些Hoxb8突变体在探索OC谱系障碍的遗传学和病理生理学以及其治疗策略方面将具有重要价值。