Kalueff Allan V, Stewart Adam Michael, Song Cai, Berridge Kent C, Graybiel Ann M, Fentress John C
Research Institute of Marine Drugs and Nutrition, Key Laboratory of Aquatic Product Processing and Safety, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Neuroscience Research Laboratory, ZENEREI Research Center, Slidell, Louisiana 70458, USA.
Nat Rev Neurosci. 2016 Jan;17(1):45-59. doi: 10.1038/nrn.2015.8. Epub 2015 Dec 17.
Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders--including models of autism spectrum disorder and obsessive compulsive disorder--that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry. Assessment of rodent self-grooming may also be useful for understanding the neural circuits that are involved in complex sequential patterns of action.
自我梳理是一种复杂的先天行为，具有进化上保守的序列模式，是啮齿动物最常进行的行为活动之一。在本综述中，我们讨论了啮齿动物自我梳理的神经生物学，并重点介绍了对神经精神疾病啮齿动物模型（包括自闭症谱系障碍和强迫症模型）的研究，这些研究评估了自我梳理表型。我们认为，啮齿动物的自我梳理可能是此类模型中重复行为的一个有用指标，因此对转化精神病学具有价值。评估啮齿动物的自我梳理也可能有助于理解参与复杂连续动作模式的神经回路。
