Grady G F, Lee V A
N Engl J Med. 1975 Nov 20;293(21):1067-70. doi: 10.1056/NEJM197511202932104.
The role of anti-HBs antibody in reducing the probability of hepatitis after accidental exposure to serum from patients with hepatitis or carriers of HBs Ag was studied prospectively among 712 medical workers. One fourth of the workers were anti-HBs positive and less than one per cent of them developed hepatitis, in contrast to 11 per cent among those who were anti-HBs negative. Three coded immune-serum globulin preparations of varying anti-HBs titer were randomly assigned. Among 251 persons passively immunized with globulin having a conventionally low anti-HBs titer, hepatitis developed in 17 (seven per cent) within six months. Comparative rates among those receiving intermediately high titer and high titer globulin, respectively, were five per cent (11 of 208) and two per cent (5 of 253). The significantly lower incidence among the latter (P less than 0.05) was offset by six additional cases, all in recipients of high titer globulin, detected when follow-up was extended to nine months.
在712名医护人员中，前瞻性地研究了抗-HBs抗体在降低意外接触肝炎患者或HBs Ag携带者血清后发生肝炎概率方面的作用。四分之一的工作人员抗-HBs呈阳性，其中不到1%的人患了肝炎，相比之下，抗-HBs呈阴性的人中有11%患了肝炎。随机分配了三种不同抗-HBs滴度的编码免疫血清球蛋白制剂。在251名被动接种常规低抗-HBs滴度球蛋白的人中，17人（7%）在六个月内患了肝炎。接受中高滴度和高滴度球蛋白的人中，相应的发病率分别为5%（208人中有11人）和2%（253人中有5人）。当随访延长至九个月时，后者（P<0.05）较低的发病率被另外6例病例抵消，这6例均为接受高滴度球蛋白的人。
