Xing H, Shen Y, Chen H, Wang Y, Shen W
Department of Internal Medicine, Xin Hua Hospital, Shanghai Second Medical University, Shanghai 200092, China.
Chin Med J (Engl). 2001 Sep;114(9):906-8.
To analyze heart rate variability (HRV) and its changes with thyroxine treatment in patients with hypothyroidism.
HRV was analyzed using 24-hour electrocardiographic recording in 38 patients with hypothyroidism and 21 normal controls. The changes in HRV were evaluated for the 18 hypothyroid patients after 3 months of thyroxine therapy.
The time domain measurements of HRV in hypothyroid patients were much lower than those in the control group. As to HRV frequency domain, the high frequency power was significantly higher, but the ratio of low frequency power to frequency power for hypothyroid patients was lower than in the controls. These abnormal changes of HRV measurements in hypothyroid patients were improved after treatment with thyroxine and were associated with recovery of serum concentrations of FT3 and FT4.
Patients with hypothyroidism often have autonomic neuropathies with a higher level of vagal tone. These abnormalities could be partly improved by thyoxine therapy.
分析甲状腺功能减退症患者的心率变异性（HRV）及其在甲状腺素治疗后的变化。
对38例甲状腺功能减退症患者和21名正常对照者进行24小时心电图记录，分析HRV。对18例甲状腺功能减退症患者进行3个月甲状腺素治疗后评估HRV的变化。
甲状腺功能减退症患者HRV的时域测量值远低于对照组。在HRV频域方面，高频功率显著更高，但甲状腺功能减退症患者的低频功率与高频功率之比低于对照组。甲状腺功能减退症患者HRV测量的这些异常变化在甲状腺素治疗后得到改善，并与血清FT3和FT4浓度的恢复相关。
甲状腺功能减退症患者常伴有自主神经病变，迷走神经张力较高。这些异常可通过甲状腺素治疗部分改善。
