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[变形链球菌耐氟突变株的诱导及其体外产酸能力的测定]

[Induction of fluoride-resistant mutant of S. mutans and the measurement of its acidogenesis in vitro].

作者信息

Sheng J, Liu Z

机构信息

Department of Oral Medicine, School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China.

出版信息

Zhonghua Kou Qiang Yi Xue Za Zhi. 2000 Mar;35(2):95-8.

PMID:11780495
Abstract

OBJECTIVE

To induce fluoride-resistant mutant of S. mutans in vitro and find out the differences of cariogenicity between them.

METHODS

Fluoride-resistant strain Ingbritt-FR was obtained by subculturing S. mutans Ingbritt to TSA and TSB containing different concentrations of fluoride. Lactic production and terminal pH of media were measured by gas chromatography method.

RESULTS

  1. The stable fluoride-resistant mutant of S. mutans Ingbritt had been induced successfully in vitro; 2. Lactic production of Ingbritt-FR was significantly more than its parent strain at various initial pH values with 0.5 and 5.0 mmol/L fluoride whereas when no fluoride existed, there were two situations: the acid production was more than S. mutans Ingbritt at initial pH above 5.0 while the result was opposite when pH was 5.0 and below.

CONCLUSION

The fluoride-resistant strain Ingbritt-FR had a stronger cariogenic potential than its parent strain S. mutans Ingbritt in physiological plaques.

摘要

目的

在体外诱导变形链球菌耐氟突变体，并找出它们之间致龋性的差异。

方法

通过将变形链球菌Ingbritt接种于含有不同浓度氟化物的TSA和TSB培养基中传代培养，获得耐氟菌株Ingbritt-FR。采用气相色谱法测定培养基的乳酸产量和终末pH值。

结果

  1. 在体外成功诱导出了稳定的变形链球菌Ingbritt耐氟突变体；2. 在含有0.5和5.0 mmol/L氟化物的各种初始pH值条件下，Ingbritt-FR的乳酸产量显著高于其亲本菌株，而在无氟存在时，有两种情况：初始pH值高于5.0时，产酸量高于变形链球菌Ingbritt，而pH值为5.0及以下时结果相反。

结论

耐氟菌株Ingbritt-FR在生理性菌斑中的致龋潜力比其亲本菌株变形链球菌Ingbritt更强。

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