Sakuma S, Doi K, Okawa H, Okaniwa A
Natl Inst Anim Health Q (Tokyo). 1975 Summer;15(2):86-93.
Articular lesions were studied in the extremities and vertebral column in murine erysipelas infection. Pathologic alterations found in those different joint systems were essentially the same in character. In the early stage of infection, phlegmon-like inflammation was observed in the periarticular loose connective tissue. Abundant fine Gram-positive bacilli were free in inflamed edematous tissue. Then, active serofibrinous exudation and emigration of leukocytes occurred in the synovial membrane, articular cartilage, annulus fibrosus, and nucleus pulposus with the development of the disease. These exudative changes disappeared gradually. Instead of them, proliferation of synovial cells accompanied by dense infiltration with lymphocytes and plasma cells became conspicuous. At the same time, chondro- and osteoclastic activity occurred in the joints of the extremities or regions adjacent to the intervertebral disk. Capsular and subchondral pannus often resulted from an excessive proliferation of granulation tissue. In the late stage, they synovial membrane and granulation tissue underwent fibrosis, adhesion and ossification. Finally, these changes resulted in fibrous or bony ankylosis and deformation. Gram-positive bacilli were hardly detected in histological preparations derived from animals in the chronic stage when proliferative change was predominant in the articular lesions.
在鼠丹毒感染中，对四肢和脊柱的关节病变进行了研究。在这些不同的关节系统中发现的病理改变在性质上基本相同。在感染早期，关节周围疏松结缔组织中观察到蜂窝织炎样炎症。在炎症水肿组织中有大量游离的革兰氏阳性细杆菌。随着疾病的发展，滑膜、关节软骨、纤维环和髓核出现了活跃的浆液纤维蛋白渗出和白细胞游出。这些渗出性改变逐渐消失。取而代之的是，滑膜细胞增殖并伴有淋巴细胞和浆细胞的密集浸润，变得明显。与此同时，在四肢关节或椎间盘相邻区域出现了软骨破坏和骨吸收活动。关节囊和软骨下血管翳常因肉芽组织过度增生而形成。在晚期，滑膜和肉芽组织发生纤维化、粘连和骨化。最后，这些变化导致纤维性或骨性强直和畸形。在关节病变以增殖性改变为主的慢性期动物的组织学标本中，很难检测到革兰氏阳性杆菌。
