Natsume T, Nakayama H, Isobe T
National Institute of Advanced Science and Technology, Biological Information Research Center (JBIRC), Tokyo, Japan.
Trends Biotechnol. 2001 Oct;19(10 Suppl):S28-33. doi: 10.1016/S0167-7799(01)01797-8.
One of the experimental processes of functional proteomics is the analysis of protein interaction. Here, we review a new analytical platform, BIA-MS, for protein interaction analysis. BIA-MS is an integration of a surface plasmon resonance biosensor for real-time interaction analysis and mass spectrometry for the subsequent identification of interacting molecules.