γ-氨基丁酸A（GABA(A)）受体δ亚基基因敲除小鼠对乙醇的行为反应存在多种缺陷。
GABA(A)-receptor delta subunit knockout mice have multiple defects in behavioral responses to ethanol.
作者信息
Mihalek R M, Bowers B J, Wehner J M, Kralic J E, VanDoren M J, Morrow A L, Homanics G E
机构信息
Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA.
出版信息
Alcohol Clin Exp Res. 2001 Dec;25(12):1708-18.
BACKGROUND
The gamma-aminobutyric acid type A receptors (GABARs) are involved in mediating some of the behavioral effects of beverage alcohol (ethanol). However, the unique pharmacological and behavioral responses conferred by each of the various receptor subunits are not well understood.
METHODS
To address the role of the GABAR delta subunit in mediating ethanol responses, gene knockout mice that lack this subunit were tested for a variety of ethanol-induced behavioral responses.
RESULTS
Our results indicate that, compared with controls, delta-deficient mice (delta-/-) have (1) reduced ethanol consumption, (2) attenuated withdrawal from chronic ethanol exposure, and (3) reduced anticonvulsant (seizure-protective) effects of ethanol. These mice demonstrate a normal anxiolytic response to ethanol and a normal hypothermic response to ethanol, and they develop both chronic and acute tolerance.
CONCLUSIONS
These results further establish the link between GABARs and specific behavioral responses to ethanol and begin to reveal the role of the delta subunit in these responses.
背景
A型γ-氨基丁酸受体（GABARs）参与介导酒精饮料（乙醇）的一些行为效应。然而，各种受体亚基各自赋予的独特药理和行为反应尚未得到充分了解。
方法
为了研究GABARδ亚基在介导乙醇反应中的作用，对缺乏该亚基的基因敲除小鼠进行了多种乙醇诱导的行为反应测试。
结果
我们的结果表明，与对照组相比，δ亚基缺陷小鼠（δ-/-）具有：（1）乙醇消耗量减少；（2）慢性乙醇暴露后的戒断反应减弱；（3）乙醇的抗惊厥（癫痫保护）作用降低。这些小鼠对乙醇表现出正常的抗焦虑反应和正常的体温降低反应，并且它们会产生慢性和急性耐受性。
结论
这些结果进一步确立了GABARs与对乙醇的特定行为反应之间的联系，并开始揭示δ亚基在这些反应中的作用。
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