Mattila P T, Svanberg M J, Jämsä T, Knuuttila M L E
Oral and Maxillofacial Department, Oulu University Hospital, Oulu, Finland.
Metabolism. 2002 Jan;51(1):92-6. doi: 10.1053/meta.2002.28105.
Our previous studies have shown that dietary xylitol protects against weakening of bone biomechanical properties in experimental postmenopausal osteoporosis. To study whether xylitol preserves bone biomechanics also during aging, a long-term experimental study was performed with rats. Twenty-four male Sprague-Dawley rats were divided into 2 groups. The rats in the control group (NON-XYL group) were fed a basal rat and mouse no. 1 maintenance (RM1) diet, while the rats in the experimental group (XYL group) were continuously fed the same diet supplemented with 10% xylitol (wt/wt). The rats were killed after 20 months. Their femurs were prepared for biomechanical analyses and scanning analyses with peripheral quantitative computed tomography (pQCT). In 3-point bending of the femoral diaphysis, maximum load, maximum elastic load, stiffness, energy absorption, elastic energy absorption, ultimate stress, and yield stress were significantly greater in the XYL group than in the NON-XYL group. This indicates a xylitol-induced improvement of both structural and material strength properties of cortical bone. Accordingly, the maximum load of femoral neck was significantly greater in the XYL group. In the pQCT analysis of femoral diaphysis, cortical bone area, cortical thickness (CtTh) periosteal circumference, and cross-sectional moment of inertia were greater in the XYL group. The endosteal circumference was smaller in the XYL group. In the pQCT analysis of the femoral neck cortical area of the midneck was significantly greater in the XYL group. This data indicates that xylitol exerted beneficial effects on the cross-sectional architecture of the bones. In conclusion, continuous moderate dietary xylitol supplementation leads to improved bone biomechanical properties in aged rats concerning both bone structural and material strength properties.
我们之前的研究表明，在实验性绝经后骨质疏松症中，膳食木糖醇可防止骨生物力学性能减弱。为了研究木糖醇在衰老过程中是否也能维持骨生物力学，我们对大鼠进行了一项长期实验研究。将24只雄性Sprague-Dawley大鼠分为2组。对照组（NON-XYL组）的大鼠喂食基础大鼠和小鼠1号维持（RM1）饲料，而实验组（XYL组）的大鼠持续喂食添加了10%木糖醇（重量/重量）的相同饲料。20个月后处死大鼠。对它们的股骨进行生物力学分析和外周定量计算机断层扫描（pQCT）扫描分析。在股骨干的三点弯曲实验中，XYL组的最大负荷、最大弹性负荷、刚度、能量吸收、弹性能量吸收、极限应力和屈服应力均显著高于NON-XYL组。这表明木糖醇可改善皮质骨的结构和材料强度性能。相应地，XYL组股骨颈的最大负荷显著更高。在股骨干的pQCT分析中，XYL组的皮质骨面积、皮质厚度（CtTh）、骨膜周长和截面惯性矩更大。XYL组的骨髓腔周长更小。在股骨颈中部皮质面积的pQCT分析中，XYL组显著更大。这些数据表明木糖醇对骨骼的横截面结构产生了有益影响。总之，持续适度补充膳食木糖醇可改善老年大鼠的骨生物力学性能，包括骨结构和材料强度性能。
