Nebra A C, Virgós B, Santos S, Tejero C, Larraga J, Araiz J J, Sánchez J I, Suárez M A, Millastre A
Servicio de Medicina Intensiva; Hospital Clínico Universitario Lozano Blesa, Zaragoza, 50009, España.
Rev Neurol. 2001;33(10):916-20.
The Real Ordinance 2070/1999 meant an important modification in the legislation, when including transcranial Doppler (TCD) in explorations to confirm the clinical diagnosis of brain death (BD). Habitually for their employment in the diagnosis of BD, we look for blood flow signal from the middle cerebral arteries (MCA) and the basilar artery (BA).
To check the effectiveness of the TCD like test of BD, looking for both middle cerebral arteries (MCA) and both intracranial vertebral arteries (VA), instead of the BA, and taking as Gold Standard cerebral scintigraphic techniques.
. We present 25 patients diagnosed clinically with BD; on these TCD was carried out to confirm BD. Later on we proceeded to carry out cerebral scintigraphic techniques in all these cases. As statistical tool the test of c2 is used with confidence interval of 95%.
In 24 of the 25 cases, the TCD was effective in confirming the diagnosis of BD. In the remaining patient, a false positive result was obtained, since the TCD didn't reveal flow in the infratentorial compartment, as contrary to the cerebral scintigraphic techniques which showed the presence of residual flow at this level; this residual flow disappeared in 36 hours. This patient was hemodynamically unstable during TCD exploration.
In our results the TCD obtains a reliability of 100% when confirming the absence of blood flow in the supratentorial compartment; nevertheless the false positive result obtained at the infratentorial level, warns us to be cautious in accepting the flow from the VA as a test of absence of flow at the infratentorial compartment, especially in those patients with hemodynamic instability.
1999年第2070号实际法令对立法进行了重大修改,将经颅多普勒(TCD)纳入用于确诊脑死亡(BD)临床诊断的检查中。在BD诊断中,我们通常会寻找大脑中动脉(MCA)和基底动脉(BA)的血流信号。
以脑闪烁显像技术作为金标准,通过寻找双侧大脑中动脉(MCA)和双侧颅内椎动脉(VA)而非基底动脉(BA),来检验TCD作为BD检测方法的有效性。
我们呈现了25例临床诊断为BD的患者;对这些患者进行TCD检查以确诊BD。随后,我们对所有这些病例进行了脑闪烁显像技术检查。作为统计工具,使用卡方检验,置信区间为95%。
25例患者中有24例,TCD能够有效确诊BD。在其余1例患者中,得到了假阳性结果,因为TCD未显示幕下区域的血流,而脑闪烁显像技术显示该水平存在残余血流;这种残余血流在36小时后消失。该患者在TCD检查期间血流动力学不稳定。
在我们的结果中,当确认幕上区域无血流时,TCD的可靠性为100%;然而,在幕下水平获得的假阳性结果提醒我们,在将椎动脉血流作为幕下区域无血流的检测方法时要谨慎,尤其是在那些血流动力学不稳定的患者中。