Szabo Susanne J, Sullivan Brandon M, Stemmann Claudia, Satoskar Abhay R, Sleckman Barry P, Glimcher Laurie H
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Science. 2002 Jan 11;295(5553):338-42. doi: 10.1126/science.1065543.
T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (TH) lymphocytes in part by activating the hallmark TH1 cytokine, interferon-gamma (IFN-gamma). IFN-gamma is also produced by natural killer (NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Although T-bet is expressed in all these cell types, it is required for control of IFN-gamma production in CD4 and NK cells, but not in CD8 cells. This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage.
T-bet是T-box转录因子家族的成员，它似乎部分通过激活标志性的辅助性T细胞1型（TH1）细胞因子γ干扰素（IFN-γ）来调节CD4辅助性T（TH）淋巴细胞的谱系定向。IFN-γ也由自然杀伤（NK）细胞产生，在CD8细胞毒性T细胞中产生最为显著，并且对控制微生物病原体至关重要。尽管T-bet在所有这些细胞类型中都有表达，但它是CD4和NK细胞中控制IFN-γ产生所必需的，而在CD8细胞中则不是。这种差异在这些细胞亚群的功能中也很明显。因此，单一细胞因子IFN-γ的调节是由T细胞谱系内不同的转录机制控制的。
