一氧化氮抗寄生虫作用的分子基础（综述）
Molecular bases for the anti-parasitic effect of NO (Review).
作者信息
Colasanti Marco, Gradoni Luigi, Mattu Marco, Persichini Tiziana, Salvati Luca, Venturini Giorgio, Ascenzi Paolo
机构信息
Dipartimento di Biologia, Università Roma Tre, I-00146 Rome, Italy.
出版信息
Int J Mol Med. 2002 Feb;9(2):131-4.
Nitric oxide (NO) has emerged as an important cytotoxic and cytostatic effector for a number of pathogens, including viruses, bacteria, fungi, and parasites. When the microbicidal effect of NO occurs, the NO-mediated S-nitrosylation of cysteine containing proteins (e.g., cysteine proteases) appears to be a common and widespread mechanism. This overview concerns parasitic cysteine proteases as NO targets, providing molecular bases for the parasiticidal effect of NO.
一氧化氮（NO）已成为多种病原体（包括病毒、细菌、真菌和寄生虫）的重要细胞毒性和细胞生长抑制效应分子。当NO发挥杀菌作用时，NO介导的含半胱氨酸蛋白质（如半胱氨酸蛋白酶）的S-亚硝基化似乎是一种常见且广泛存在的机制。本综述关注作为NO作用靶点的寄生性半胱氨酸蛋白酶，为NO的杀寄生虫作用提供分子基础。
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