Bundow D, Rosoff L, Aboulafia D M
Division of Gastroenterology, Virginia Mason Medical Center, Seattle, USA.
AIDS Read. 2001 Nov;11(11):577-80.
The cases of 2 patients with nevirapine-associated hepatotoxicity in conjunction with rash and eosinophilia are reported here. Both patients' conditions improved following withdrawal of nevirapine. Previous case reports have described a variety of interventions other than drug withdrawal that might have contributed to resolution of drug-induced hepatitis. Until a better understanding of the clinical spectrum and pathophysiology of nevirapine-associated hepatotoxicity is realized, treatment will remain largely empiric.
本文报告了2例出现奈韦拉平相关肝毒性并伴有皮疹和嗜酸性粒细胞增多的病例。停用奈韦拉平后，两名患者的病情均有所改善。先前的病例报告描述了除停药之外的多种干预措施，这些措施可能有助于药物性肝炎的消退。在对奈韦拉平相关肝毒性的临床谱和病理生理学有更好的了解之前，治疗仍将主要基于经验。
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